Evidence map›Paper›PMID 41251136›Full record

ArticleNucleic acids research2026

TWAS atlas 2.0: an updated data resource for transcriptome-wide association studies.

Hao Gao, Congfan Bu, Si Zheng, Jialin Mai, Jinbei Wang, Rui Tang, Zhuojing Fan, Jingyao Zeng, Jiao Li, Jingfa Xiao

Abstract read
In one paragraph

Article in Nucleic acids research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. AI semantics for biomedical data integration.bioRxiv : the preprint server for biology · 2026
    Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Hao GaoNational Genomics Data Center, China National Center for Bioinformation, Beijing 100101, China.
Congfan BuNational Genomics Data Center, China National Center for Bioinformation, Beijing 100101, China.ORCID 0000-0002-6592-6977
Si ZhengInstitute of Medical Information, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100020, China.ORCID 0000-0002-9834-9774
Jialin MaiNational Genomics Data Center, China National Center for Bioinformation, Beijing 100101, China.
Jinbei WangInstitute of Medical Information, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100020, China.
Rui TangInstitute of Medical Information, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100020, China.
Zhuojing FanNational Genomics Data Center, China National Center for Bioinformation, Beijing 100101, China.ORCID 0009-0003-3575-6967
Jingyao ZengNational Genomics Data Center, China National Center for Bioinformation, Beijing 100101, China.ORCID 0000-0001-7364-9677
Jiao LiInstitute of Medical Information, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100020, China.
Jingfa XiaoNational Genomics Data Center, China National Center for Bioinformation, Beijing 100101, China.ORCID 0000-0002-2835-4340

Funding

Chinese Academy of Sciences XDA0460202National Key R&D Program of China 2024YFA1307701National Natural Science Foundation of China 32300542Youth Innovation Promotion Association of the Chinese Academy of Sciences 2022098
6 · The paper itself

Abstract

Transcriptome-wide association studies (TWAS), which combine large-scale GWAS and expression quantitative trait loci (eQTL) datasets to predict gene expression levels and identify trait-related genes, have recently been applied across many traits. TWAS Atlas is a comprehensive public resource that carefully curates TWAS results from a standard set of literature, helping researchers integrate and analyze numerous gene-trait associations. In TWAS Atlas 2.0 (https://ngdc.cncb.ac.cn/twas/), we not only include the latest high-quality TWAS findings but also incorporate GWAS datasets for performing TWAS analysis to expand the range of covered phenotypes, increasing gene-trait associations from 401 226 to 676 198, involving 590 traits and 24 870 genes. The knowledge graph has been significantly enhanced and enriched through information extraction from literature, now featuring new capabilities that greatly improve its usability and analytical power. We have developed multidimensional interactive analysis modules, including functional enrichment, Mendelian randomization, colocalization, and fine-mapping, providing researchers with comprehensive tools to explore causal relationships between genes and traits. These updates significantly enhance the utility of TWAS Atlas 2.0, facilitating a deeper understanding of gene expression and its regulation of complex traits.

Indexed as

Databases, GeneticGenome-Wide Association StudyQuantitative Trait LociTranscriptomeGene Expression ProfilingHumansPhenotypePolymorphism, Single NucleotideSoftware

Identifiers

PMID41251136
PMCPMC12807705

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.