ArticleAnnals of medicine2025
Clinical significance of the systemic immune-inflammation index in relation to pathology, treatment and outcomes in acute appendicitis: a retrospective study.
Article in Annals of medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Response to letter regarding clinical significance of the systemic immune inflammation index in relation to pathology treatment and outcomes in acute appendicitis a retrospective study.Annals of medicine · 2026Article
- Comment on 'clinical significance of the systemic immune-inflammation index in relation to pathology, treatment, and outcomes in acute appendicitis: a retrospective study'.Annals of medicine · 2026Article
- Leukoglycemic index and inflammatory markers in acute abdominal pain: Comparison of non-specific pain and acute appendicitis severity.Langenbeck's archives of surgery · 2026Article
- Diagnostic value of CAR, HALP, and SII for predicting complicated appendicitis: a reassessment of inflammatory indices.BMC surgery · 2026Article
- Aerobic and Facultative Bacterial Spectrum and Antimicrobial Susceptibility Patterns in Pediatric Acute Appendicitis: A Prospective Local Surveillance Study.International journal of microbiology · 2026Article
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Authors and funding
7 authors.
Funding
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Abstract
introductionAcute appendicitis is a common abdominal emergency. Systemic Immune-Inflammation Index (SII) is a biomarker reflecting immune status and inflammatory response, but its role in acute appendicitis remains poorly characterized. This study aims to investigate the potential diagnostic and therapeutic value of SII for assessing infection severity and prognosis in acute appendicitis. MATERIALS AND
methodsThis retrospective study analyzed clinical data from patients with acute appendicitis admitted to our hospital. The SII was the primary exposure variable and calculated as SII = platelet count × neutrophil count /lymphocyte count. Outcome variables included length of stay and total hospitalization costs. Covariates included age, sex, admission time, body temperature, shock status, comorbidities, hemoglobin, procalcitonin, presence of fecalith on computed tomography (CT), placement of intraoperative drainage tubes, and postoperative pathological classification.
resultsThe study included 2,458 patients with acute appendicitis. Surgically treated patients had significantly higher SII than conservatively managed patients (2077.76 vs. 1526.80). SII was positively correlated with the pathological severity of acute appendicitis (
conclusionsSII is a valuable diagnostic tool in patients with acute appendicitis, offering a quantitative basis for clinical decision-making.
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