Evidence map›Paper›PMID 41250997›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026

Neutrophil Extracellular Trap Reprograms Cancer Metabolism to Form a Metastatic Niche Promoting Non-Small Cell Lung Cancer Brain Metastasis.

Bo Chen, Karrie M Kiang, Fangkun Liu, Chuntao Li, Xizhe Li, Chen Weiwei, Xin Fu, Gelei Xiao, Jingyi Sun, Erhan Da and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Leveraging Microphysiological Systems to Facilitate Neutrophil-Based Cancer Immunotherapy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Review
  2. Review
  3. Review
  4. Review
  5. Article
  6. Review
  7. Article
  8. Review
  9. Review
  10. Review
  11. Article
  12. Review
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Bo ChenDepartment of Neurosurgery, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, Hunan, 410008, China.ORCID https://orcid.org/0000-0003-0812-5775
Karrie M KiangDepartment of Surgery, School of Clinical Medicine, LKS Faculty of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong SAR, China.
Fangkun LiuDepartment of Neurosurgery, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, Hunan, 410008, China.
Chuntao LiDepartment of Neurosurgery, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, Hunan, 410008, China.
Xizhe LiDepartment of Thoracic Surgery, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, Hunan, 410008, China.
Chen WeiweiDepartment of Clinical Oncology, School of Clinical Medicine, LKS Faculty of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong SAR, China.
Xin FuThe State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, 54 Xianlie South Rd, Guangzhou, 510060, China.
Gelei XiaoDepartment of Neurosurgery, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, Hunan, 410008, China.
Jingyi SunDepartment of Respiratory Medicine, Hunan Provincial People's Hospital (The First-Affiliated Hospital of Hunan Normal University), 61 Jiefang Xi Road, Changsha, Hunan, 410005, China.
Erhan DaDepartment of Neurosurgery, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, Hunan, 410008, China.
Junbo LiaoDepartment of Neurosurgery, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, Hunan, 410008, China.
Hongshu ZhouDepartment of Neurosurgery, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, Hunan, 410008, China.
Li MengDepartment of Radiology, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, Hunan, 410008, China.
Li ZhouDepartment of Pathology, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, Hunan, 410008, China.
Tao SongDepartment of Neurosurgery, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, Hunan, 410008, China.
Longbo ZhangDepartment of Neurosurgery, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, Hunan, 410008, China.ORCID https://orcid.org/0000-0002-9077-3239
Gilberto Ka-Kit LeungDepartment of Surgery, School of Clinical Medicine, LKS Faculty of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong SAR, China.
Liyang ZhangDepartment of Neurosurgery, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, Hunan, 410008, China.ORCID https://orcid.org/0000-0002-4054-1667

Funding

"Innovation Leading Figure" FundInnovative Research Group Project of the National Natural Science Foundation of China 82171171Innovative Research Group Project of the National Natural Science Foundation of China 82371183Jiangxi Provincial Natural Science Foundation 20252BAC240435Jiangxi Provincial Natural Science Foundation 2025BAC240442National Clinical Research Center for Geriatric Diseases Clinical Research Fund 2023LNJJ19National Natural Science Foundation of China 82403157Natural Science Foundation of Hunan Province 2023JJ0897Natural Science Foundation of Hunan Province 2023JJ30972Science Fund for Distinguished Young Scholars of Hunan Province 2024JJ2091
6 · The paper itself

Abstract

Non-small cell lung cancer (NSCLC) is the leading cause of brain metastases (BMs) and is characterized by a poor prognosis and limited response to standard treatments. Multi-omics sequencings, integrating spatial transcriptomics, metabolomics, single-cell RNA sequencing, bulk proteomics, and metabolomics, are conducted to analyze tumor and blood specimens from 34 patients with NSCLC with or without BMs from the Xiangya Hospital NSCLC (XY-NSCLC) and Queen Mary Hospital NSCLC (QMH-NSCLC) cohorts. This investigation identified LOX

Indexed as

Brain NeoplasmsCarcinoma, Non-Small-Cell LungExtracellular TrapsLung NeoplasmsNeutrophilsAnimalsCell Line, TumorEpithelial-Mesenchymal TransitionFemaleHumansMaleMiceTumor Microenvironmentbrain metastasismetabolic reprogrammingmetastasis‐initiating cellsneutrophil extracellular trapsnon‐small cell lung cancer

Identifiers

PMID41250997
PMCPMC12850224

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.