ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026
Enhanced Recognition via Defect Engineered Amorphous Metal-Organic Framework for Sensitive and Stable Pesticide Biosensor.
Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Confined Catalysis of Enzymes: Enhancement Strategies, Materials, and Biosensor Applications.Journal of functional biomaterials · 2026Review
- Enhanced Recognition via Defect Engineered Amorphous Metal-Organic Framework for Sensitive and Stable Pesticide Biosensor.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
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Authors and funding
8 authors.
Funding
Abstract
Enzyme-based biosensors with rapid and on-site detection capabilities possess great potential for practical application. However, conventional enzyme immobilization strategies often enhance stability at the expense of substantial enzyme activity loss, thereby limiting the detection performance of enzyme-based biosensors. Herein, a highly sensitive and robust biosensor is constructed based on defect-engineered amorphous metal-organic frameworks, enabling on-site detection of organophosphate pesticides in complex food matrices. Defective acetylcholinesterase@amorphous metal-organic frameworks (denoted as AChE@AMOF-74) can be in situ tailored via a defect-engineered strategy to provide a suitable microenvironment and obtain high porosity for enzyme encapsulation, while its porous architecture enhances the catalytic activity of immobilized enzyme. Impressively, the catalysis activity and target recognition ability of AChE@AMOF-74 are 3.4-fold and 5.6-fold higher than those of nanoarchitectures with a regular crystalline structure. Benefiting from the structural advantages, a robust AChE@AMOF-74-based biosensor is constructed for the sensitive detection of pesticides, enabling quantitative analysis of paraoxon with a detection limit of 0.05 ng·mL
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Registered trials
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