ArticleMaternal & child nutrition2026
First-Trimester Serum n-3/n-6 Fatty Acids Predict Large-for-Gestational-Age Risk: A Nested Case-Control Study.
Article in Maternal & child nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Polyunsaturated fatty acids (PUFAs) are critical for fetal development during pregnancy. This study evaluates the association between maternal serum n-3 and n-6 PUFAs in early pregnancy and the risk of large-for-gestational-age (LGA) infants. A nested case-control study was conducted with 45 LGA-appropriate for gestational age (AGA) matched pairs from a cohort of 2839 pregnant women. Maternal serum samples collected during early pregnancy were analyzed for lipid profiles using gas chromatography-mass spectrometry (GC-MS). Associations between fatty acid levels and LGA risk were assessed using Spearman correlation, chi-square tests, and logistic regression. The results indicated that higher arachidonic acid (ARA, p = 0.024) and docosahexaenoic acid (DHA, p = 0.039) levels were positively correlated with LGA risk. Linoleic acid (LA, p = 0.009), alpha-linolenic acid (ALA, p = 0.040), and the n-6/n-3 PUFA ratio (p = 0.034) were negatively correlated with LGA. Adjusted odds ratios indicated that higher quartiles of ARA (OR = 2.293, p = 0.078) and DHA (OR = 2.593, p = 0.038) increased LGA risk, while higher n-6 PUFA levels reduced the risk (OR = 0.340, p = 0.019). In conclusion, early pregnancy serum n-3 and n-6 PUFA levels are associated with LGA risk. Elevated ARA and DHA levels may increase LGA risk, while higher n-6 PUFA levels may be protective. These findings suggest that PUFA levels could serve as early indicators for targeted nutritional interventions.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.