ArticleAnnals of clinical and translational neurology2026
Network Localization of Fatigue in Multiple Sclerosis.
Article in Annals of clinical and translational neurology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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Who cites it
2 citing papers in PubMed.
- Presence and Impact of Fatigue in Patients With Multiple Sclerosis.Medical science monitor : international medical journal of experimental and clinical research · 2026Observational
- Network Localization of Fatigue in Multiple Sclerosis.Annals of clinical and translational neurology · 2026Article
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Authors and funding
13 authors.
Funding
Abstract
backgroundFatigue is among the most common symptoms and one of the main factors determining the quality of life in multiple sclerosis (MS). However, the neurobiological mechanisms underlying fatigue are not fully understood. Here we studied lesion locations and their connections in individuals with MS, aiming to identify brain networks associated with fatigue.
methods38 MS patients with and 21 without fatigue were included in the study. Association between fatigue and lesion locations was investigated using voxel-lesion symptom mapping and lesion connectivity using lesion network mapping. The findings were tested in two independent datasets, including (1) MS patients scanned using resting-state functional connectivity MRI (rs-fcMRI) (n = 199) and (2) individuals with stroke lesions (n = 85).
resultsThere were no specific anatomical MS lesion locations significantly associated with fatigue, but lesions associated with fatigue were connected to a common network with peak positive connectivity to the right premotor cortex and negative connectivity to the left temporal pole (p
conclusionsOur results show that fatigue in MS localizes to a brain network, lending insight into the neural substrates of fatigue.
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