ArticleAlzheimer's & dementia (New York, N. Y.)
Evaluation of self-mediated alternatives for risk testing education and return of results (eSMARTER) study: A randomized study of methods for returning
Article in Alzheimer's & dementia (New York, N. Y.). The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06459583 (Evaluation of Self-Mediated Alternatives for Risk Testing Education and Return of Results), which is not on this map. Cited by 5 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Evaluation of Self-Mediated Alternatives for Risk Testing Education and Return of Results
Who cites it
5 citing papers in PubMed.
- CONNECT4 APOE: A randomized trial of telephone versus real-time two-way videoconference for disclosure of APOE genotype results in cognitively unimpaired adults.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Trial
- Willingness and barriers to blood-based biomarker testing of Alzheimer's disease in the general population in the Czech Republic.Alzheimer's research & therapy · 2026Article
- Now is the time: the need to update guidance to expand access toFrontiers in dementia · 2026Article
- Impact of learning APOE genotype on cognitively unimpaired adults: a pre-screening cohort study of the Alzheimer's Prevention Initiative Generation Study 1.The lancet. Healthy longevity · 2025Article
- Evaluation of self-mediated alternatives for risk testing education and return of results (eSMARTER) study: A randomized study of methods for returningAlzheimer's & dementia (New York, N. Y.)Article
Corrections and comments
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Authors and funding
16 authors.
Funding
Abstract
introductionDisclosing Alzheimer's disease (AD) genetic and biomarker information is becoming increasingly common but often resource-intensive, requiring a clinician to return results. As results become relevant for clinical care and more people want to learn their results, scalable approaches to disclosure are needed. Here, we describe the design of a decentralized, randomized, non-inferiority clinical trial (eSMARTER) to evaluate self-directed scalable digital methods for returning APOE and plasma pTau-217 results.
methodsParticipants (
resultsData collection is ongoing. Results will allow for non-inferiority comparisons between clinician- and self-mediated disclosure of APOE results and initial characterization of the impact of learning pTau-217 results. DISCUSSION: The eSMARTER Study represents an important step towards meeting expected increases in demand for learning AD genetic and biomarker information. The digital platforms developed for this study will be made available to support clinicians and investigators returning genetic and/or biomarker results. Highlights: Novel, scalable design for self-mediated disclosure of
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