ArticlePeerJ2025
Assessment of serum diagnostic biomarkers for periprosthetic joint infection in hip and knee arthroplasty: a retrospective study.
Article in PeerJ, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- Key Inflammatory Pathways, Biomarkers, and Targeted Management Strategies in Primary Total Joint Arthroplasty: A Narrative Review.Medicina (Kaunas, Lithuania) · 2026Review
- From serum inflammatory markers to fluid, tissue, and molecular assays: current advances in the laboratory diagnosis of bone and joint infections.Frontiers in cellular and infection microbiology · 2026Review
- The diagnostic value of platelet-related indicators to CRP ratio in periprosthetic joint infection.Frontiers in cellular and infection microbiology · 2026Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Periprosthetic joint infection (PJI) after total hip and knee arthroplasty is challenging to differentiate from similar afflictions. Platelet count-to-mean platelet volume (PC/MPV) ratio has been proposed, but requires validation. This study evaluated PC/MPV and other potential serological biomarkers for diagnosing PJI prior to reimplantation arthroplasty of the hip and knee. Material and Methods: Medical records were retrospectively reviewed of patients who received hip and knee revision, and there were 88 PJI patients and 156 non-PJI patients met the modified 2018 criteria for inclusion. Receiver operating characteristic curves (ROCs) were used to analyze and compare the diagnostic performances of PC/MPV, fibrinogen (FIB), C-reactive protein (CRP), platelet count (PLT), erythrocyte sedimentation rate (ESR), and serum white blood cell (WBC) count. Results: Compared with the control group, the patients with PJI had significantly higher PC/MPV, FIB, ESR, CRP, serum WBC, and PLT, respectively, and the areas under the ROC curve were 0.787, 0.917, 0.832, 0.934, 0.685, and 0.778; that of FIB and CRP were similar. Regarding PC/MPV, the optimal cutoff was 27.81, and the sensitivity, specificity, and positive and negative predictive values were 0.807, 0.673, 0.582, and 0.861. Conclusions: The best diagnostic performance was achieved by CRP and FIB, and we recommend that these tests should be prioritized. Serum WBC, PC/MPV and PLT were insufficient to predict PJI prior to reimplantation arthroplasty of the hip and knee; however, CRP combined with FIB or PC/MPV best serves to obtain the most accurate prediction of PJI in our study.
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