ArticleCureus2025
Quantifying Color Variegation in Melanoma Lesions Using Shannon Entropy.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Color variegation is a key dermoscopic sign for melanoma, but lacks objective measurement. We computed Shannon entropy (H) from histograms of smartphone images (iPhone 13 Pro Max) of a histopathologically confirmed superficial spreading melanoma, a benign melanocytic nevus, and their perilesional skin as controls. Relative entropy (ΔH) was calculated to account for baseline skin heterogeneity. Absolute H values were 6.94 (melanoma), 6.67 (nevus), 5.75 (elderly perilesional skin), and 4.39 (young perilesional skin), with ΔH of +1.19 and +2.28, respectively. Entropy differentiated lesions from healthy skin, while ΔH highlighted baseline variability. Limitations include the single-case design, manual region-of-interest delineation, and non-standardized smartphone imaging without controlled lighting or dermoscopic magnification. Shannon entropy provides a reproducible, quantitative measure of color variegation, with potential applications in teledermatology and low-resource settings. Future studies should assess reproducibility across larger cohorts and standardized imaging modalities.
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