Evidence map›Paper›PMID 41250706›Full record

ArticleCureus2025

A Polyendocrine Puzzle: Unravelling Schmidt Syndrome (Autoimmune Polyendocrine Syndrome Type II) Presenting in Crisis.

Shadman Sakib Rahman, Nusrat A Chowdhury, Nandakumar Poonthottam, Sumaiya Kamal, Mohammad Arif Sarwar

Abstract readCase Reports
In one paragraph

Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Shadman Sakib RahmanInternal Medicine, Medway NHS Foundation Trust, Kent, GBR.
Nusrat A ChowdhuryInternal Medicine, Medway NHS Foundation Trust, Kent, GBR.
Nandakumar PoonthottamInternal Medicine, Medway NHS Foundation Trust, Kent, GBR.
Sumaiya KamalAcute Medicine, Medway Maritime Hospital, Gillingham, GBR.
Mohammad Arif SarwarAcute Medicine, Medway NHS Foundation Trust, Kent, GBR.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Schmidt syndrome is a rare autoimmune disorder with polygenic inheritance that results in damage to specific organs due to lymphocytic infiltration. It is characterised by the coexistence of at least two of the following: Addison's disease, autoimmune thyroid disease (Graves' disease or hypothyroidism) and type 1 diabetes mellitus (T1DM). We report such a rare case, in which a 34-year-old woman presented with symptoms of adrenal insufficiency and was diagnosed with Schmidt syndrome. Prompt recognition, patient education and long-term multidisciplinary follow-up are essential for optimal management of such conditions. Empirical glucocorticoid therapy before a definitive diagnosis was crucial in the management of such a crisis. This case highlights the rarity and diagnostic challenges of this syndrome, in which nonspecific symptoms, along with overlapping autoimmune conditions, may delay diagnosis and subsequent management.

Indexed as

addisonian crisisaddison’s diseaseautoimmune disorderautoimmune polyendocrine syndrome type iiautosomal dominant inheritancegraves’ diseasehydrocortisoneprimary adrenal insufficiencyshort synacthen teststeroid

Identifiers

PMID41250706
PMCPMC12619965

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.