ArticleAlzheimer's & dementia (Amsterdam, Netherlands)
Inner and outer retinal abnormalities detected in Alzheimer's disease subjects diagnosed by amyloid PET not revealed when classified based on clinical criteria.
Article in Alzheimer's & dementia (Amsterdam, Netherlands). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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3 citing papers in PubMed.
- The Machine Learning Classification of Retinal Ganglion Cell Dendritic Texture in a 3xTg-Alzheimer's Disease Mouse Model.Diagnostics (Basel, Switzerland) · 2026Article
- Electroretinography as a non-invasive biomarker for early detection of cognitive impairment in older adults: A scoping review protocol.PloS one · 2026Article
- Inner and outer retinal abnormalities detected in Alzheimer's disease subjects diagnosed by amyloid PET not revealed when classified based on clinical criteria.Alzheimer's & dementia (Amsterdam, Netherlands)Article
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13 authors.
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Abstract
backgroundPrevious studies on retinal changes in Alzheimer's disease (AD) using optical coherence tomography (OCT) and electroretinography (ERG) based on clinical diagnostic criteria have yielded inconsistent results. We evaluated retinal structure and function in subjects classified using clinical and biological definitions.
methodsFifty-nine included subjects underwent comprehensive neuropsychiatric and ophthalmic evaluations, including OCT and ERG with photopic negative response (PhNR). Amyloid status was determined by
resultsNo significant differences in evaluated OCT and ERG parameters were found between cognitively impaired and unimpaired groups. Amyloid-positive subjects showed significantly thinner macular, inner plexiform, and inner nuclear layers, plus ERG abnormalities (reduced PhNR, smaller waves amplitudes, prolonged a-wave latency) ( DISCUSSION: Biomarker-based classification revealed retinal changes, affecting both inner retina and photoreceptors, not detected using clinical criteria. Highlights: Retinal studies in Alzheimer's disease yield mixed results when based on clinical criteria.Amyloid positron emission tomography classification permits recognition of retinal changes missed clinically.Optical coherence tomography (OCT) shows early macular thinning in amyloid beta positive subjects at the expense of inner layers.Electroretinography detects outer retinal dysfunction, indicating broader involvement.Retinal function loss on electroretinography precedes inner/outer changes on OCT.
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