Trial reportJournal of Korean medical science2025
Impact of Intravascular Fluid Resuscitation on Whole Blood Viscosity During Endovascular Detachable Coiling Procedure for Unruptured Intracranial Aneurysm: A Prospective Randomized Controlled Trial.
Trial report in Journal of Korean medical science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02700607 (Impact of Intravascular Fluid Resuscitation on Whole Blood Viscosity During Coiling Embolization Procedure for Cerebral Artery Aneurysm), which is not on this map. Not yet cited in PubMed.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Impact of Intravascular Fluid Resuscitation on Whole Blood Viscosity During Coiling Embolization Procedure for Cerebral Artery Aneurysm
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Authors and funding
6 authors.
Funding
Abstract
backgroundWhole blood viscosity (WBV) determines wall shear stress, representing dynamic force and contributing to aneurysmal remodeling. We hypothesized that administering balanced crystalloid (Group-C) or hydroxyethyl starch (HES) 130/0.4 (Group-HES) for IV fluid management would have a different impact on high-shear WBV during the endovascular detachable coiling (EDC).
methodsThirty EDC patients randomly got HES (Group-HES, n = 15) or crystalloid (Group-C, n = 15) as the main IV fluid resuscitation during the procedure. The WBV at a shear rate of 300 sec
resultsThe median (25-75%) volume of infused crystalloid was 800 (700, 1,200) mL in Group-C and those of HES and crystalloid were 400 (150, 750) and of 500 (400, 600) mL in Group-HES, respectively. Pre-WBV₃₀₀ showed no significant inter-group difference. However, Post-WBV₃₀₀ in Group-HES was significantly lower than in Group-C (3.40 ± 0.33 vs. 3.95 ± 0.79 centipoise,
conclusionOur study showed that HES infusion provided significantly lower WBV than crystalloid infusion during the EDC procedure. Further study is warranted to determine whether the lower WBV after HES infusion would enhance clinical outcomes.
trial registrationClinicalTrials.gov Identifier: NCT02700607.
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