SynthesisJournal of Korean medical science2025
Varicella Vaccine Effectiveness and Duration of Protection: A Systematic Review and Meta-Analysis.
Synthesis in Journal of Korean medical science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Varicella vaccination in children with nephrotic syndrome.Pediatric nephrology (Berlin, Germany) · 2026Article
- Effectiveness of varicella vaccine during a varicella outbreak in a Chinese senior high school: a retrospective cohort study.Frontiers in immunology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
backgroundThis study provides a comprehensive review of studies comparing the effectiveness of varicella vaccinations and the duration of their protection.
methodsWe conducted a systematic literature review to identify comparative studies evaluating the effectiveness of the varicella vaccine. A meta-analysis was performed to assess the effectiveness of one-dose and two-dose vaccinations, as well as the outcomes for moderate and severe illness, and the duration of protection, using random effects models.
resultsOut of 66 studies, 57 reported the effectiveness of a single-dose varicella vaccine, 28 examined the two-dose vaccination, and 25 focused on effectiveness against moderate to severe disease. Of these, 59 were observational studies and 7 were trials. Thirteen studies reported the duration of protection. The overall vaccine effectiveness for a single dose was 79% (76-82%; I² = 97.2%), while for two doses, it was 94% (93-96%; I² = 90.8%). The overall effectiveness against moderate or severe illness was 92% (90-94%; I² = 90.3%). The duration of protection showed a slight decline over time. Evidence suggests that both one and two doses of the varicella vaccine offer short-term protection, though this protection wanes rapidly.
conclusionThe two-dose vaccination demonstrated superior clinical efficacy compared to the one-dose vaccination, with protection slightly diminishing over time. These findings highlight the importance of implementing universal two-dose varicella vaccination programs in countries.
trial registrationPROSPERO Identifier: CRD42024589864.
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