ArticleEuropean journal of medical research2025
Global burden of paralytic ileus and intestinal obstruction in young and middle-aged adults (15-49 years): a systematic analysis from global burden of disease study 2021.
Article in European journal of medical research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Quetiapine-induced paralytic ileus in a male patient in his 40s with polypharmacy.Journal of rural medicine : JRM · 2026Article
- Global, Regional, and National Burden of Acute Abdominal Conditions in Females-Appendicitis, Ectopic Pregnancy, Paralytic Ileus and Intestinal Obstruction, and Urolithiasis, 1990-2021: A Systematic Analysis for the Global Burden of Disease Study 2021 with ARIMA Projections to 2030.International journal of women's health · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe global burden of disease of paralytic ileus and intestinal obstruction (PIAIO) in young and middle-aged adults (15-49 years) has not been systematically assessed. This study is the first to quantitatively analyze the epidemiological characteristics of PIAIO and its association with socioeconomic development level in this population, to reveal its spatiotemporal heterogeneity and health inequality.
methodsData from 204 countries and territories in GBD 2021 were included in this study, and incidence, prevalence, mortality, and disability-adjusted life years (DALYs) were estimated using Bayesian hierarchical modeling with cause of death ensemble modeling. Socioeconomic gradients were assessed by socio-demographic index (SDI) stratification and health inequality analysis. Bayesian age-period-cohort modeling was applied to project disease trends.
resultsGlobally, in 2021, there were 5.61 million new cases of PIAIO, 215,681 prevalent cases, 32,885 deaths, and 1.86 million DALYs lost in people aged 15-49 years. During 1990-2021, age-standardized incidence rate (ASIR) and prevalence rate (ASPR) showed a slight upward trend (AAPC 0.06% and 0.05%), but mortality (ASMR) and DALYs rates decreased significantly (AAPC - 0.80% and - 0.74%). High SDI regions had the highest ASIR (153.28/100,000) and ASPR (5.90/100,000), while Eastern Sub-Saharan Africa had the highest ASMR (3.54/100,000) and DALYs rate (181.53/100,000) globally. At national level, India carries the highest absolute burden, with the highest ASIR of 251.27/100,000 in Japan and the highest ASMR of 6.04/100,000 in Mozambique. Between 1990 and 2021, the ASMR and DALYs rates gradient showed a narrowing of absolute inequality, but relative inequality widened. The absolute number of new cases is projected to increase by 14.2% through 2036, with the ASMR declining by only 0.79 (95% UI: 0.39-1.19) per 100,000 persons-year.
conclusionsYoung and middle-aged PIAIO showed a global pattern of "high diagnosis in high-income regions and high mortality in low-income regions." Although advances in surgical techniques have contributed to the decline in mortality, increasing incidence and persistent health inequalities in low SDI regions call for targeted interventions. This study fills the gap in evidence on the burden of disease in this population, and it is necessary to combine data from multiple sources to improve precise prevention and control strategies.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.