Evidence map›Paper›PMID 41250167›Full record

ArticleReproductive biology and endocrinology : RB&E2025

Hyperbaric oxygen therapy improves oocyte yield and embryo quality in poor ovarian responders: a pre-post cohort study.

Wenjia Meng, Wanqiu Zhu, Ziyi Song, Ye Pan, Xiuye Xing, Jing Guo, Lihong Pang, Fanwei Meng, Ziye Zhang, Jiachen Li and 2 more

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In one paragraph

Article in Reproductive biology and endocrinology : RB&E, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

12 authors.

Wenjia Meng *Medical Center for Human Reproduction, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, 100020, China.
Wanqiu Zhu *Department of Hyperbaric Oxygen, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, 100020, China.
Ziyi SongMedical Center for Human Reproduction, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, 100020, China.
Ye PanMedical Center for Human Reproduction, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, 100020, China.
Xiuye XingMedical Center for Human Reproduction, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, 100020, China.
Jing GuoMedical Center for Human Reproduction, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, 100020, China.
Lihong PangMedical Center for Human Reproduction, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, 100020, China.
Fanwei MengMedical Center for Human Reproduction, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, 100020, China.
Ziye ZhangMedical Center for Human Reproduction, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, 100020, China.
Jiachen LiEvidence-Based Medicine Center, Beijing Institute of Respiratory Medicine, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, 100020, China.
Jing YangDepartment of Hyperbaric Oxygen, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, 100020, China. yangjinghbo@163.com.
Qun LuMedical Center for Human Reproduction, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, 100020, China. luqun1023@sina.com.

Funding

the Beijing Chaoyang Hospital Multidisciplinary Clinical Research Innovation Team Project CYDXK202203the National Key Technology Research and Development Program of China 2022YFC2704404
6 · The paper itself

Abstract

backgroundPoor ovarian response (POR) is characterized by low oocyte yield, poor embryo quality, high cycle cancellation rates during controlled ovarian stimulation, and poor pregnancy outcomes. This study aimed to evaluate the potential of hyperbaric oxygen therapy (HBOT) in improving ovarian response, enhancing oocyte retrieval and embryo quality, and identifying the optimal HBOT regimen for POR patients.

methodsA pre-post cohort study included 41 women aged 20–45 with POR to compare oocyte yield and embryo quality pre-post HBOT. Restricted cubic spline (RCS) regression analyzed the relationship between HBOT and the number of oocytes. A generalized estimating equation (GEE) model assessed the impact of HBOT on oocytes, normal fertilization rate, and available embryos rate.

resultsPaired analysis revealed that HBOT significantly increased the number of oocytes, follicle output rate (FORT), follicle-to-oocyte index (FOI), two-pronuclear (2PN), available embryos, normal fertilization rate, and available embryos rate. A nonlinear relationship was found between HBOT sessions and oocyte number (P-nonlinear = 0.016), which showed the oocytes rose significantly after two HBOT sessions, plateaued at four to seven sessions, and showed no further increase beyond eight sessions.

conclusionsCombining the controlled ovarian stimulation process with 4–7 sessions of HBOT could improve oocyte number and embryo quality in POR patients.

trial registrationThis is a pre-post cohort study. Clinical trial number: not applicable.

Indexed as

Hyperbaric OxygenationOocyte RetrievalOocytesOvulation InductionAdultCohort StudiesFemaleFertilization in VitroHumansPregnancyPregnancy RateYoung AdultEmbryo qualityHyperbaric oxygen therapyPoor ovarian response

Identifiers

PMID41250167
PMCPMC12621376

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LicenceCC BY-NC-ND
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.