SynthesisJournal of neuroengineering and rehabilitation2025
Effect of exercise-based interventions on stroke rehabilitation: an umbrella review of systematic reviews and meta-analyses.
Synthesis in Journal of neuroengineering and rehabilitation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Comparative effectiveness of exercise interventions on postural balance and activity ability in stroke patients: a systematic review and network meta-analysis.BMC neurology · 2026Pooled it
- Tai Ji for stroke rehabilitation: a randomized controlled trial on improving upper limb function and cortico-muscular coupling in stroke patients.Journal of neuroengineering and rehabilitation · 2026Trial
- Association of Cardiovascular Risk Burden with Cardiorespiratory Fitness and Functional Performance in Patients with Post-Stroke Spasticity: A Retrospective Observational Study.Journal of clinical medicine · 2026Article
- High-Intensity Interval Training on Cardiorespiratory Fitness, Cognitive Function, and Functional Capacity in Adults with Stroke: A Systematic Review and Meta-Analysis.Journal of clinical medicine · 2026Review
- Aerobic exercise enhances α-tubulin lactylation and neurological recovery after ischemic stroke.Cell & bioscience · 2026Article
- Kinesiophobia in older patients after stroke: a mixed-methods study using a life-course perspective.BMC geriatrics · 2026Article
- Recent research on rehabilitation interventions for post-stroke gait and balance in low- and middle-income countries: a scoping review.BMC health services research · 2026Article
- Intensity over duration in neurological rehabilitation: exploring evidence for optimised recovery paradigms.Frontiers in neurology · 2025Article
- Exercise modulation of BDNF/TrkB signaling in Parkinson's disease: an evidence-calibrated review of neuroprotective mechanisms, biomarker limitations, and translational gaps.Frontiers in neurologyReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDespite the extensive evidence available, a systematic synthesis and quality evaluation of exercise-based interventions for stroke rehabilitation is still lacking.
methodsWe systematically searched PubMed, Embase, Web of Science, and Cochrane Library. Study quality and evidence certainty were evaluated using AMSTAR, JBI, ROBIS, and GRADE frameworks. Intervention efficacy was analyzed against functional metrics, with an in-depth analysis of intensity, dosage, and recovery stage.
resultsInitially, 4367 studies were retrieved, of which 144 were included. After categorization according to the predefined criteria, 51 articles were included in the final data analysis. The umbrella review revealed that exercise-based interventions primarily improved patients' physical function, mobility, and participation. Specifically, exercise enhanced neuromotor control (BBS: MD [1.35 to 13.17]; TIS: MD [2.46 to 4.32]), musculoskeletal function (FMA-LE: MD [2.44 to 3.05]), cardiopulmonary and metabolic function (VO
conclusionExercise-based interventions are effective at all stages of stroke recovery, improving physical function, mobility, and participation. Individuals in the acute phase benefit from core stability exercises combined with bed rest. Individuals in the subacute phase should focus on strength training, supplemented by constraint-induced movement therapy. Individuals in the chronic phase are advised to engage in aerobic exercise supplemented by activities such as Tai Chi and exergaming. PROSPERO registration number: No. CRD42025637376.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.