ArticleMalaria journal2025
Optimal control analysis of malaria infection in children under 5 years and pregnant women under the influence of temperature.
Article in Malaria journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
3 authors.
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Abstract
backgroundMalaria remains a major global public health problem, particularly affecting children under 5 years of age and pregnant women in regions where temperatures are favorable for transmission. Despite continuous control efforts, malaria continues to pose a significant health and economic burden, underscoring the need for rigorous quantitative assessment of intervention strategies.
methodsA mathematical model was developed to analyse and evaluate the impact of three control measures: treatment of infected individuals, the use of LLINs, and indoor residual spraying (IRS). Due to the nature of the available data, the analysis was initiated with the model incorporating treatment. The effective reproduction number (
resultsNumerical simulations of the model with treatment indicate that treating infected individuals is an effective approach to reducing malaria transmission. When the three control strategies were tested individually, treatment of infectious humans was found to be more effective than either spraying insecticides or using LLINs alone. In combined strategies, the use of LLINs together with treatment emerged as the most effective control approach. Notably, applying all three controls simultaneously did not yield a significant improvement compared to the combination of LLINs and treatment.
conclusionsThis study demonstrates that combining LLINs with the treatment of infected individuals provides the most cost-effective and efficient strategy for managing malaria transmission. These findings highlight the importance of integrating personal protection and prompt treatment in malaria control programs, particularly in high-transmission settings.
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