Evidence map›Paper›PMID 41250088›Full record

ArticleParasites & vectors2025

Is a shortened postoperative albendazole duration after curative surgery for alveolar echinococcosis possible? Results from a prospective multicenter study.

Paul Calame, Carine Richou, Oleg Blagosklonov, Frederic Grenouillet, Alexandra Heurgué, Isabelle Villena, Emilia Frentiu, Celia Turco, Gabriel Simon, ECHINOVISTA Group and 2 more

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Parasites & vectors, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Paul CalameDepartment of Radiology, University Marie and Louis Pasteur and University Hospital Besançon, 25030, Besançon, France. p1calame@chu-besancon.fr.
Carine RichouNational Reference Center for Echinococcoses, Department of Parasitology-Mycology, University Hospital Besançon, 25030, Besançon, France.
Oleg BlagosklonovNational Reference Center for Echinococcoses, Department of Parasitology-Mycology, University Hospital Besançon, 25030, Besançon, France.
Frederic GrenouilletLaboratory of Fungi and Parasite Serology, University Marie and Louis Pasteur and University Hospital Besançon, 25030, Besançon, France.
Alexandra HeurguéDepartment of Gastroenterology and Hepatology, University Hospital of Reims, 51092, Reims, France.
Isabelle VillenaDepartment of Parasitology, University Hospital of Reims, 51092, Reims, France.
Emilia FrentiuDepartment of Infectious Disease, University Hospital of Nancy, 54511, Vandoeuvre-Lès-Nancy, France.
Celia TurcoDepartment of Digestive Surgery, University Marie and Louis Pasteur and University Hospital Besançon, 25030, Besançon, France.
Gabriel SimonDepartment of Radiology, University Marie and Louis Pasteur and University Hospital Besançon, 25030, Besançon, France.
ECHINOVISTA Group
Dominique-Angèle VuittonSchool of Health Sciences, University Marie and Louis Pasteur, 25030, Besançon, France.
Solange Bresson-HadniNational Reference Center for Echinococcoses, Department of Parasitology-Mycology, University Hospital Besançon, 25030, Besançon, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In a prospective study of 15 patients with liver alveolar echinococcosis who underwent curative surgery, a strategy to reduce the recommended 2-year postoperative albendazole (ABZ) regimen was evaluated. Guided by negative positron emission tomography computed tomography (PET-CT) and magnetic resonance imaging (MRI) results at 1 year, ABZ was safely discontinued earlier (median 14 months) in 10 patients, with no recurrence observed during the mean 47 months of follow-up, indicating that postoperative ABZ may be safely shortened with careful imaging follow-up. Interestingly, a retrospective analysis of the rEm18AB antibody index showed that a negative index was not required for ABZ withdrawal, although a declining trend supported the decision.

Indexed as

AlbendazoleAnthelminticsEchinococcosisEchinococcosis, HepaticAdultAgedFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedPositron Emission Tomography Computed TomographyPostoperative PeriodProspective StudiesRetrospective StudiesTreatment OutcomeAlbendazoleAnthelminticsAlbendazoleAlveolar echinococcosisCurative surgeryEchinococcus multilocularisrEm18-ELISA

Identifiers

PMID41250088
PMCPMC12625319

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.