ArticleLipids in health and disease2025
Joint association of different insulin resistance-related indices and moderate-to-vigorous physical activity with risk of cardiometabolic disease and multimorbidity: insights from the UK Biobank prospective cohort study.
Article in Lipids in health and disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors.
Funding
Abstract
backgroundInsulin resistance (IR)-related indices and moderate-to-vigorous physical activity (MVPA) were independent predictors for cardiometabolic disease (CMD) and multimorbidity (CMM), but their combined effect is unclear. We aimed to investigate their joint effect on incident CMD and CMM.
methodsThis study was conducted from the UK Biobank accelerometer sub-study. The IR-related indices included triglyceride-glucose index (TyG), TyG-body mass index (TyG-BMI), TyG-waist circumference (TyG-WC), TyG-waist-to-height ratio (TyG-WHtR), and metabolic score for IR (Mets-IR). Participants were divided according to the median values of IR-related indices and MVPA time. Cox regression was used to assess the associations between different groups and outcomes, with interaction effects estimated.
results74,367 participants were included. Compared to participants with low TyG index and high MVPA, the adjusted HR (aHR) for CMD was 1.71 (95% CI: 1.55-1.88) for high TyG and low MVPA. The corresponding aHR were 1.82 (95%CI: 1.66-1.99) for TyG-BMI, 1.96 (95%CI: 1.77-2.17) for TyG-WC, 1.88 (95%CI: 1.71-2.07) for TyG-WHtR, and 1.90 (95%CI: 1.73-2.09) for Mets-IR, with significant additive interactions. Similar associations were observed in incident CMM.
conclusionsIR-related indices and MVPA had synergistic effects in incident CMD and CMM, highlighting the importance of identification and prevention for CMD and CMM.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.