ArticleAnnals of clinical microbiology and antimicrobials2025
Genomic insights into novel ST7947 carbapenem-resistant hypervirulent Klebsiella pneumoniae: a threat from an Indian hospital setting.
Article in Annals of clinical microbiology and antimicrobials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed, 1 synthesis or guideline pooled it.
- Risk factors for invasiveFrontiers in cellular and infection microbiology · 2026Pooled it
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe rise of carbapenem-resistant hypervirulent Klebsiella pneumoniae (CR-hvKp) strains represents a major clinical threat, particularly in Asia. These strains possess both extensive drug resistance and enhanced virulence traits, leading to high morbidity and mortality. This study aimed to characterize the genomic profile of a CR-hvKp isolate (BB-7) obtained from a clinical case in eastern India and to investigate its resistance and virulence mechanisms.
methodsK. pneumoniae BB-7 was obtained from the urine sample of a 75-year-old male and identified by using the VITEK2 system and ITS-PCR amplification. Hypervirulence was confirmed through the string test and detection of the iucA gene. The antimicrobial susceptibility (AST) was determined by the Kirby-Bauer disk diffusion method, whereas colistin susceptibility was measured using broth microdilution. Whole-genome sequencing was performed using Illumina NovaSeq, followed by de novo assembly, annotation, and resistome/virulome analysis using tools including PROKKA, CARD, ResFinder, and VFAnalyzer. MLST, plasmid typing, capsular serotyping, phage element, and insertion element were analyzed by using an online database. Phylogenetic analysis was performed using cgMLST and core SNP approaches.
resultsBB-7 exhibited an extensively drug-resistant (XDR) phenotype, including resistance to β-lactams, fluoroquinolones, aminoglycosides, tetracyclines, and colistin. Resistance genes identified included bla
conclusionBB-7 represents a novel CR-hvKp strain with a unique ST7947 genotype, exhibiting co-resistance and hypervirulence, raising concern for public health. The association of high-risk resistance plasmids with virulence factors underscores the urgent need for enhanced genomic surveillance, infection control, and devising specific therapies to restrict the proliferation of such strains.
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