Observational studyBMC public health2025
Transition from HIV post-exposure prophylaxis to pre-exposure prophylaxis and awareness-to-use cascade among men who have sex with men: a longitudinal study in Guangxi, China.
Observational study in BMC public health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed, 1 synthesis or guideline pooled it.
- Effectiveness of community-based PrEP delivery for men who have sex with men: a global systematic review and meta-analysis.Frontiers in public health · 2026Pooled it
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors.
Funding
Abstract
backgroundHIV post-exposure prophylaxis (PEP) and pre-exposure prophylaxis (PrEP) are effective yet underutilized HIV prevention modalities. This study aims to evaluate the awareness-to-use cascade for PEP and PrEP, and to examine the transition from PEP to PrEP among men who have sex with men (MSM). We will discuss the rationale for using PrEP after PEP use.
methodsWith an observational, longitudinal study design, MSM were recruited from five cities in Guangxi, China. Participants completed questionnaires every 3 months and were tracked for 12 months. Descriptive statistics summarized the awareness, use, cascade and transition of PEP and PrEP. The effect of PEP use on PrEP use was analyzed using Generalized Estimating Equations.
resultsA total of 363 eligible MSM were recruited, and 350 participants completed at least one follow-up visit. Overall, at baseline, 96.7% were aware of PEP, and 15.2% used it. 76.0% were aware of PrEP, and 5.2% used it. According to baseline and follow-up surveys, of the 68 participants who used PEP, 29.4% reported initiating PrEP after a PEP course; of these, 60.0% did so after a single course. The median number of PEP uses before transitioning was 1 (interquartile range [IQR]: 1 to 2.5). The median time interval for transitioning from PEP to PrEP was 11 months (IQR: 4 to 18 months). After adjusting for sociodemographic and sexual behavior factors, having previously used PEP is one of the main predictors of PrEP use (adjusted odds ratio [AOR] 5.45, 95% CI: 1.80-16.50).
conclusionsAlthough awareness of PEP and PrEP among MSM in Guangxi, China was high, the proportion of participants initiating PEP and PrEP remained low. It is recommended that effective support and screening for transitioning to PrEP be provided after a successful first use of PEP to promote the broader implementation of HIV prevention measures.
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