ArticleBMC endocrine disorders2025
Estimation of cortisol exposure in patients with adrenal incidentalomas.
Article in BMC endocrine disorders, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- The cardiometabolic significance of post-dexamethasone cortisol levels below the MACS threshold in adrenal incidentaloma.Endocrine · 2026Article
- A longitudinal study of dual-energy X-ray absorptiometry status in menopausal women with adrenal tumors.Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologieArticle
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
contextAdrenal incidentaloma (AI) guidelines classify patients with suppressed 1 mg dexamethasone suppression test cortisol (F) below 50nmol/l as non-functioning in terms of cortisol autonomy and denies the necessity of metabolic follow-up. However, cardiometabolic risk and disturbed quality of life was shown in those patients. We aimed to establish daily cortisol exposure by salivary cortisol sampling at three different time frames and evaluate whether patients with suppressed (F) are exposed to cortisol excess.
designCross-sectional and prospective. PATIENTS: In 138 AI patients referred to our unit, 101 patients were enrolled. We included healthy volunteers without any adrenal disorders (n = 30) and patients with Cushing’s syndrome evaluated during the study timeline (n = 16). Adrenal incidentaloma patients were divided into categories with respect to (F). MEASUREMENTS: Anthropometric characteristics, previous history of cardiovascular events, plasma corticotrophin (ACTH), serum dehydroepiandrostenadione-sulfate (DHEAS) and (F) were recorded. Saliva collection for the assessment of cortisol concentration was performed at the morning (SLCMN), afternoon (SLCAN) and late night (SLCLN).
resultsSLCAN and SLCLN of AI patients, irrespective of their F levels, were significantly increased when compared to healthy controls. Further analysis showed that SLCAN and SLCLN concentrations were significantly elevated in patients with F [25-49nmol/l] compared to healthy controls. Diurnal rhythm of cortisol had a similar pattern in healthy controls and all AI subjects irrespective of their F category while the amplitude of secretion was concordant with F.
conclusionsAdrenal incidentaloma patients categorized as non-functioning by the current criteria of (F), could feature an increased exposure cortisol secretion. CLINICAL TRIAL NUMBER: Not applicable.
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