Evidence map›Paper›PMID 41249998›Full record

Observational studyBMC gastroenterology2025

Early lactate and its metabolism for predicting persistent renal failure in patients with acute pancreatitis: a retrospective observational study.

Jianhua Wan, Huajing Ke, Wenhua He, Yin Zhu, Nonghua Lu, Liang Xia

Erratum issuedAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in BMC gastroenterology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Jianhua Wan *Department of Gastroenterology, Jiangxi Provincial Key Laboratory of Digestive Diseases, Jiangxi Clinical Research Center for Gastroenterology, Digestive Disease Hospital, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, 17 Yongwaizheng Street, Nanchang, Jiangxi, 330006, People's Republic of China.
Huajing Ke *Department of Gastroenterology, Jiangxi Provincial Key Laboratory of Digestive Diseases, Jiangxi Clinical Research Center for Gastroenterology, Digestive Disease Hospital, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, 17 Yongwaizheng Street, Nanchang, Jiangxi, 330006, People's Republic of China.
Wenhua HeDepartment of Gastroenterology, Jiangxi Provincial Key Laboratory of Digestive Diseases, Jiangxi Clinical Research Center for Gastroenterology, Digestive Disease Hospital, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, 17 Yongwaizheng Street, Nanchang, Jiangxi, 330006, People's Republic of China.
Yin ZhuDepartment of Gastroenterology, Jiangxi Provincial Key Laboratory of Digestive Diseases, Jiangxi Clinical Research Center for Gastroenterology, Digestive Disease Hospital, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, 17 Yongwaizheng Street, Nanchang, Jiangxi, 330006, People's Republic of China.
Nonghua LuDepartment of Gastroenterology, Jiangxi Provincial Key Laboratory of Digestive Diseases, Jiangxi Clinical Research Center for Gastroenterology, Digestive Disease Hospital, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, 17 Yongwaizheng Street, Nanchang, Jiangxi, 330006, People's Republic of China.
Liang XiaDepartment of Gastroenterology, Jiangxi Provincial Key Laboratory of Digestive Diseases, Jiangxi Clinical Research Center for Gastroenterology, Digestive Disease Hospital, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, 17 Yongwaizheng Street, Nanchang, Jiangxi, 330006, People's Republic of China. xialiang79@163.com.

Funding

National Natural Science Foundation of China 82560136 and 82560137Natural Science Foundation of Jiangxi Province 20242BAB25438Project for Academic and Technical Leaders of Major Disciplines in Jiangxi Province 20243BCE51144The First Affiliated Hospital of Nanchang University Clinical Research and Cultivation Project YFYKCTDPY202202
6 · The paper itself

Abstract

Acute pancreatitis (AP) is common and clinically complex, and persistent renal failure (PRF) is a severe complication. This study retrospectively analyzed 798 AP patients admitted within three days of onset and divided them into a PRF group (n = 111) and a non-PRF group (n = 687), comparing the characteristics of the two groups. Multivariate analysis showed that lactate (β = 0.340, P < 0.001, OR = 1.405) and lactate dehydrogenase (LDH, β = 0.002, P < 0.001, OR = 1.002) were significant risk factors for PRF. Stratified analysis indicated that patients with LDH ≥ 700 U/L and lactate ≥ 2 mmol/L had a higher incidence of PRF. The ROC curve analysis showed that the areas under the curve for lactate, LDH, and the combined lactate + LDH were 0.752, 0.828, and 0.866, respectively, with the highest diagnostic accuracy for the combined indicator. The characteristics of different risk groups showed that the incidence of PRF in the high-risk group was significantly higher than that in the low-risk group. The levels of lactate and LDH within 24 h of admission have a significant predictive effect on PRF in AP patients, which helps clinicians identify high-risk patients early and guide treatment decisions.

Indexed as

Lactic AcidL-Lactate DehydrogenasePancreatitisRenal InsufficiencyAcute DiseaseAdultAgedBiomarkersFemaleHumansMaleMiddle AgedPredictive Value of TestsRetrospective StudiesRisk FactorsROC CurveBiomarkersLactic AcidL-Lactate DehydrogenaseAcute pancreatitisLactateLactate dehydrogenasePersistent renal failurePrognosis

Identifiers

PMID41249998
PMCPMC12625738

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.