Evidence map›Paper›PMID 41249927›Full record

ArticleBMC geriatrics2025

Echocardiographic study of myocardial work in elderly type 2 diabetes mellitus patients with microalbuminuria.

Heling Wen, Hui Li, Min Hong, Wenjie Tian, Lei Peng, Yu Chen

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Article in BMC geriatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Heling Wen *Department of Cardiology, Sichuan Academy of Medical Science &Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, 610072, China.
Hui Li *Department of Ultrasonography, Fuwai Hospital, Chinese Academy of Medical Sciences, Beijing, 100037, China.
Min Hong *Center for Health Management, Sichuan Academy of Medical Science & Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China.
Wenjie TianDepartment of Cardiology, Sichuan Academy of Medical Science &Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, 610072, China. tianwenjie1976@hotmail.com.
Lei PengDepartment of Nephrology, Sichuan Academy of Medical Science &Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, 610072, China. cloudy_hit@163.com.
Yu ChenDepartment of Cardiology, Sichuan Academy of Medical Science &Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, 610072, China. yuchenpatric@uestc.edu.cn.

Funding

Chengdu Science and Technology Bureau 2024-YF05-01712-SNSichuan Provincial Medical Association Medical Research Project S2024022the Chengdu Medical Grant 2024026the Department of Science and Technology of Sichuan Province 2024NSFSC0688the National Natural Science Foundation of China No. 81600259the National Natural Science Foundation of China No. 82200767the "PRO•Run" Fund of the Nephrology Group of CEBM KYJ202206-0003-1
6 · The paper itself

Abstract

backgroundType 2 diabetes mellitus (T2DM) combined with microalbuminuria (MAU) is an increasingly serious health issue, particularly among the elderly, often accompanied by severe complications such as heart failure (HF). This study aims to evaluate early changes in left ventricular (LV) myocardial work in T2DM patients with MAU using the LV pressure-strain loop (PSL) technique.

methodsThe study included 50 elderly patients with T2DM, 50 elderly patients with T2DM combined with MAU, and 50 healthy elderly controls. Based on conventional echocardiography and two-dimensional speckle tracking echocardiography, the PSL technique was used to measure LV myocardial work parameters.

resultsWe observed significant differences in cardiac function parameters between elderly T2DM patients with and without MAU. Compared with the normal control group, elderly T2DM patients showed significant reductions in GLS, GWI, GCW, and GWE, while GWW was significantly increased. Additionally, T2DM patients with MAU had significantly lower GWI and GWE than those without MAU, and the MAU group had significantly higher GWW compared to the non-MAU group.

conclusionsIn this study, MAU exacerbated the impairment of LV systolic function in T2DM patients. Myocardial work techniques can serve as a more sensitive clinical method for evaluating LV systolic function in elderly T2DM patients with MAU.

trial registrationChinese Clinical Registry Center, ChiCTR2400094052 (prospectively registered), Date: 12-16-2024.

Indexed as

AlbuminuriaDiabetes Mellitus, Type 2EchocardiographyVentricular Function, LeftAgedFemaleHumansMaleEchocardiographyLeft ventricle functionMicroalbuminuriaMyocardial workPressure-strain loopType 2 diabetes mellitus

Identifiers

PMID41249927
PMCPMC12625267

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.