Trial reportBMC geriatrics2025
Comparison of remimazolam and dexmedetomidine for conscious sedation in elderly patients undergoing dental implant surgery: a prospective randomized controlled trial.
Trial report in BMC geriatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Efficacy and Safety of Dexmedetomidine-Esketamine Versus Dexmedetomidine Alone as Premedication for Pediatric Anesthesia Induction: A Systematic Review, Meta-Analysis, and Trial Sequential Analysis.Paediatric anaesthesia · 2026Pooled it
- Pharmacological vs. non-pharmacological interventions for anxiety control in dental implant surgery: a systematic review.Frontiers in dental medicine · 2026Pooled it
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe objective of this study was to compare the efficacy and safety of remimazolam and dexmedetomidine in elderly patients undergoing dental implant surgery.
methodsSeventy-four elderly patients aged 65-80 years and scheduled for dental implant surgery were randomly divided into two groups. Patients in Group R received a 0.05 mg/kg loading dose of remimazolam over 1 min and followed by an infusion rate 0.1-0.3 mg/kg/h. In Group D, a 0.5 µg/kg bolus of dexmedetomidine was given over 10 min and followed by an infusion rate 0.2-1.0 µg/kg/h. The primary outcome of the study was the incidence of hypotension between the two groups. Secondary outcomes were perioperative complications, hemodynamic and respiratory variables, sedation and recovery profiles.
resultsThe incidence of hypotension in Group R was significantly lower than that in Group D (5.4% vs. 24.3%, RR: 0.22, 95% CI: 0.05-0.96, P = 0.022). The difference of bradycardia was not significant between Group R and Group D (2.6% vs. 13.5%, RR: 0.20, 95% CI: 0.02-1.63, P = 0.088). Only one patient in Group D experienced transient hypoxemia lasting less than 10 s. The onset of sedation was much faster in Group R than Group D (105 ± 21 s vs. 599 ± 172 s, P < 0.01). Two patients in Group D did not reach the target sedative level in 15 min after sedative infusion. All patients reached a MOAA/S score of 5 upon completion of the dental implant surgery. However, patients in Group D had a higher incidence of delayed discharge than those in Group R (16.2% vs. 2.7%, P = 0.047).
conclusionsBoth remimazolam and dexmedetomidine can provide satisfactory sedation with minimal inhibition on respiratory function in elderly patients undergoing dental implant surgery. However, remimazolam is superior to dexmedetomidine, offering better hemodynamic stability, faster onset of sedation, and quicker recovery.
trial registrationThis study was registered at the Chinese Clinical Trials Registry (Registration ID: ChiCTR2400083062; Registration date: April 15, 2024).
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