ArticleBMC neurology2025
A case report of CLIPPERS syndrome with gait and cognitive impairment.
Article in BMC neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Case Report: Probable CLIPPERS in a patient with cutaneous T-cell lymphoma in remission: 5-year follow-up.Frontiers in immunology · 2026Article
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Authors and funding
5 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundChronic Lymphocytic Inflammation with Pontine Perivascular Enhancement Responsive to Steroids (CLIPPERS) syndrome is a rare, chronic inflammatory central nervous system (CNS) disorder. It primarily involves the brainstem and cerebellum, presenting with subacute neurological symptoms. CASE PRESENTATION: A 44-year-old male presented with progressive gait imbalance, cognitive dysfunction, and behavioral changes over six weeks. Neurological examination revealed a wide-based unsteady gait, cerebellar dysmetria, and mild cognitive deficits. Cerebrospinal fluid (CSF) analysis showed lymphocytic pleocytosis and elevated protein, while infectious and neoplastic causes were ruled out. Brain MRI demonstrated nodular and patchy lesions involving the cerebellum, brainstem, and thalamus, with characteristic pepper-like post-contrast enhancement consistent with CLIPPERS syndrome. TREATMENT AND OUTCOME: High-dose intravenous methylprednisolone (1 g/day for 5 days) led to significant clinical improvement, including resolution of gait disturbance and cognitive deficits. Follow-up MRI showed a marked reduction in lesion size. Maintenance therapy with oral methotrexate was initiated to sustain remission.
conclusionCLIPPERS syndrome should be considered in patients presenting with subacute pontocerebellar dysfunction and characteristic MRI findings. Early diagnosis and prompt corticosteroid therapy can lead to favorable outcomes. Long-term immunosuppressive treatment is essential to prevent relapse. Careful follow-up is required to monitor for recurrence and potential malignant transformation.
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