Evidence map›Paper›PMID 41249857›Full record

ArticleCNS neuroscience & therapeutics2025

CXCL10 Involvement in Vestibular Migraine via the PI3K/AKT Signaling Pathway.

Mao-Mei Song, Ting-Yan Chen, Shi-Na Song, Ying-Jie Gao, Chang-Xin Li, Sui-Yi Xu

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Article in CNS neuroscience & therapeutics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Mao-Mei SongDepartment of Neurology, Headache Center, The First Hospital of Shanxi Medical University, Taiyuan, China.ORCID 0000-0002-9288-8726
Ting-Yan ChenDepartment of Neurology, Headache Center, The First Hospital of Shanxi Medical University, Taiyuan, China.ORCID 0009-0003-0691-5578
Shi-Na SongDepartment of Neurology, Headache Center, The First Hospital of Shanxi Medical University, Taiyuan, China.
Ying-Jie GaoDepartment of Neurology, Headache Center, The First Hospital of Shanxi Medical University, Taiyuan, China.ORCID 0009-0007-2061-7111
Chang-Xin LiDepartment of Neurology, Headache Center, The First Hospital of Shanxi Medical University, Taiyuan, China.ORCID 0000-0001-8652-4283
Sui-Yi XuDepartment of Neurology, Headache Center, The First Hospital of Shanxi Medical University, Taiyuan, China.ORCID 0000-0002-8908-011X

Funding

Shanxi Applied Basic Research Program 202303021221222
6 · The paper itself

Abstract

aimsC-X-C motif chemokine ligand 10 (CXCL10) is a member of the CXC chemokine family, known as a classical pain-related chemokine. While CXCL10 is implicated in neuropathic pain, its role in vestibular migraine (VM) remains unclear.

methodsSerum CXCL10 levels correlated with dizziness and headache severity in VM patients. In the rat VM model, CXCL10, C-X-C motif chemokine receptor 3 (CXCR3), and phosphatidylinositol 4,5-bisphosphate 3-kinase (PI3K)/protein kinase B (AKT) signaling pathway expression were evaluated to explore the potential mechanisms of CXCL10 in VM.

resultsSerum CXCL10 levels in VM patients were significantly elevated and positively correlated with headache and dizziness severity. In the rat VM model, CXCL10 and CXCR3 expression in the trigeminal nucleus caudalis and vestibular nuclei were significantly increased. Additionally, molecules related to the PI3K/AKT signaling pathway and downstream inflammatory factors showed significantly elevated expression.

conclusionCXCL10 activates the PI3K/AKT signaling pathway, promoting the release of inflammatory factors, including interleukin-1β, interleukin-6, and tumor necrosis factor-α, and is thus involved in the pathogenesis of VM.

Indexed as

Chemokine CXCL10Migraine DisordersPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktSignal TransductionVestibular DiseasesAdultAnimalsDisease Models, AnimalFemaleHumansMaleMiddle AgedRatsRats, Sprague-DawleyReceptors, CXCR3Chemokine CXCL10CXCL10 protein, humanPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktReceptors, CXCR3chemokineCXCR3dizzinessinflammatory cytokinespain thresholdtrigeminal nucleus caudalisvertigovestibular nuclei

Identifiers

PMID41249857
PMCPMC12623153

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.