Evidence map›Paper›PMID 41249843›Full record

ArticleNature genetics2025

African-ancestry-specific variant IKKβ p.Glu502Lys confers high lupus risk.

Gudny Ella Thorlacius, Erna V Ivarsdottir, Saedis Saevarsdottir, Kristjan H S Moore, Sigurjon A Gudjonsson, Bjarni V Halldorsson, Hilma Holm, Aslaug Jonasdottir, Frosti Jonsson, Snaedis Kristmundsdottir and 19 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature genetics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

29 authors.

Gudny Ella Thorlacius *Amgen deCODE Genetics, Reykjavik, Iceland. gudny.thorlacius@decode.is.ORCID http://orcid.org/0000-0001-8997-4327
Erna V Ivarsdottir *Amgen deCODE Genetics, Reykjavik, Iceland.ORCID http://orcid.org/0000-0002-2069-0681
Saedis SaevarsdottirAmgen deCODE Genetics, Reykjavik, Iceland.
Kristjan H S MooreAmgen deCODE Genetics, Reykjavik, Iceland.ORCID http://orcid.org/0000-0002-9579-4362
Sigurjon A GudjonssonAmgen deCODE Genetics, Reykjavik, Iceland.
Bjarni V HalldorssonAmgen deCODE Genetics, Reykjavik, Iceland.ORCID http://orcid.org/0000-0003-0756-0767
Hilma HolmAmgen deCODE Genetics, Reykjavik, Iceland.
Aslaug JonasdottirAmgen deCODE Genetics, Reykjavik, Iceland.
Frosti JonssonAmgen deCODE Genetics, Reykjavik, Iceland.
Snaedis KristmundsdottirAmgen deCODE Genetics, Reykjavik, Iceland.
Gisli MassonAmgen deCODE Genetics, Reykjavik, Iceland.
Olafur T MagnussonAmgen deCODE Genetics, Reykjavik, Iceland.
Gudmundur L NorddahlAmgen deCODE Genetics, Reykjavik, Iceland.
Asmundur OddssonAmgen deCODE Genetics, Reykjavik, Iceland.
Thorunn A OlafsdottirAmgen deCODE Genetics, Reykjavik, Iceland.
Pall I OlasonAmgen deCODE Genetics, Reykjavik, Iceland.
Aron SkaftasonAmgen deCODE Genetics, Reykjavik, Iceland.
Lilja StefansdottirAmgen deCODE Genetics, Reykjavik, Iceland.
Arni SturlusonAmgen deCODE Genetics, Reykjavik, Iceland.
Unnur ThorsteinsdottirAmgen deCODE Genetics, Reykjavik, Iceland.
Gudmar ThorleifssonAmgen deCODE Genetics, Reykjavik, Iceland.
Valentin Y WalkerAmgen deCODE Genetics, Reykjavik, Iceland.
Florian ZinkAmgen deCODE Genetics, Reykjavik, Iceland.
Eirikur SteingrimssonDepartment of Biochemistry and Molecular Biology, BioMedical Center, Faculty of Medicine, University of Iceland, Reykjavik, Iceland.ORCID http://orcid.org/0000-0001-5826-7486
Daniel F GudbjartssonAmgen deCODE Genetics, Reykjavik, Iceland.
Ingileif JonsdottirAmgen deCODE Genetics, Reykjavik, Iceland.
Agnar HelgasonAmgen deCODE Genetics, Reykjavik, Iceland.ORCID http://orcid.org/0000-0002-8545-3767
Patrick SulemAmgen deCODE Genetics, Reykjavik, Iceland.
Kari StefanssonAmgen deCODE Genetics, Reykjavik, Iceland. kstefans@hi.is.ORCID http://orcid.org/0000-0003-1676-864X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cutaneous lupus erythematosus (CLE) is an autoimmune disease of the skin, occurring with or without systemic lupus erythematosus (SLE). People with African ancestry have a higher risk than people with other ancestries of developing lupus

Indexed as

Black or African AmericanBlack PeopleGenetic Predisposition to DiseaseI-kappa B KinaseLupus Erythematosus, CutaneousLupus Erythematosus, SystemicAdultFemaleGenome-Wide Association StudyHumansMaleMiddle AgedMutation, MissensePolymorphism, Single NucleotideI-kappa B KinaseIKBKB protein, human

Identifiers

PMID41249843
PMCPMC12695626

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.