Evidence map›Paper›PMID 41249838›Full record

ArticleNature biotechnology2025

Extensive restoration of forelimb function in primates with spinal cord injury by neural stem cell transplantation.

Eleni Sinopoulou, Ephron S Rosenzweig, John H Brock, Hiromi Kumamaru, Ernesto A Salegio, Michael J Castle, Janet L Weber, Rachele Wurr, Ryan Macon, Michelle W Chow and 9 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature biotechnology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
  2. Article
  3. Engineering Silk Fibroin-Based Biomaterials for Neural Repair.Advanced materials (Deerfield Beach, Fla.) · 2026
    Review
  4. Transcriptomics Insights into Spinal Cord Injury for Therapy Development.International journal of molecular sciences · 2026
    Review
  5. Article
  6. Review
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Eleni Sinopoulou *Dept. of Neurosciences, University of California, San Diego, La Jolla, CA, USA.
Ephron S Rosenzweig *Dept. of Neurosciences, University of California, San Diego, La Jolla, CA, USA.ORCID http://orcid.org/0000-0002-0370-9643
John H BrockDept. of Neurosciences, University of California, San Diego, La Jolla, CA, USA.
Hiromi KumamaruDept. of Neurosciences, University of California, San Diego, La Jolla, CA, USA.
Ernesto A SalegioDept. of Neurosurgery, University of California, San Francisco, San Francisco, CA, USA.
Michael J CastleDept. of Neurosciences, University of California, San Diego, La Jolla, CA, USA.
Janet L WeberDept. of Neurosciences, University of California, San Diego, La Jolla, CA, USA.
Rachele WurrCalifornia National Primate Research Center, University of California, Davis, Davis, CA, USA.
Ryan MaconCalifornia National Primate Research Center, University of California, Davis, Davis, CA, USA.
Michelle W ChowDept. of Neurosciences, University of California, San Diego, La Jolla, CA, USA.
J Russell HuieDept. of Neurosurgery, University of California, San Francisco, San Francisco, CA, USA.
Nikos KyritsisDept. of Neurosurgery, University of California, San Francisco, San Francisco, CA, USA.ORCID http://orcid.org/0000-0001-7801-5796
Leif A HavtonDepartments of Neurology and Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Yvette S Nout-LomasCollege of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO, USA.ORCID http://orcid.org/0000-0001-6583-2308
Carolyn J SparreyMechatronic Systems Engineering, Simon Fraser University, Surrey, British Columbia, Canada.ORCID http://orcid.org/0000-0002-5524-4577
Adam R FergusonDept. of Neurosurgery, University of California, San Francisco, San Francisco, CA, USA.ORCID http://orcid.org/0000-0001-7102-1608
Michael S BeattieDept. of Neurosurgery, University of California, San Francisco, San Francisco, CA, USA.ORCID http://orcid.org/0000-0001-9463-3631
Jacqueline C BresnahanDept. of Neurosurgery, University of California, San Francisco, San Francisco, CA, USA.
Mark H TuszynskiDept. of Neurosciences, University of California, San Diego, La Jolla, CA, USA. mtuszynski@ucsd.edu.ORCID http://orcid.org/0000-0003-4182-1481

Funding

Plasticity and Regeneration in the Primate Spinal CordR01NS042291 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BRESNAHAN, JACQUELINE C, CAPITANIO, JOHN P · 2001 to 2015
$13.0M
The Primate Corticospinal Connectome and Transcriptome - SupplementR01NS104442 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI TUSZYNSKI, MARK H. · 2017 to 2025
$5.7M
Embryonic stem cell therapy after cervical contusion SCI in NHPsR01NS105478 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BEATTIE, MICHAEL S, BRESNAHAN, JACQUELINE C · 2017 to 2021
$2.9M
Embryonic Stem Cell Therapy after Cervical Contusion SCI in NHPsR01NS130033 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI JACQUELINE C BRESNAHAN, Michael S Beattie · 2023 to 2026
$2.6M
Canadian Network for Research and Innovation in Machining Technology, Natural Sciences and Engineering Research Council of Canada (NSERC Canadian Network for Research and Innovation in Machining Technology) RGPIN - 2018 - 06382NINDS NIH HHS R01 NS042291NINDS NIH HHS R01 NS104442NINDS NIH HHS R01 NS105478NINDS NIH HHS R01 NS130033RRD VA I01 RX002245RRD VA I50 RX001706U.S. Department of Health & Human Services | NIH | National Institute of Neurological Disorders and Stroke (NINDS) NS104442U.S. Department of Health & Human Services | NIH | National Institute of Neurological Disorders and Stroke (NINDS) NS105478U.S. Department of Health & Human Services | NIH | National Institute of Neurological Disorders and Stroke (NINDS) R-01 NS105478
6 · The paper itself

Abstract

Research on cell therapy for spinal cord injury has yet to achieve sufficient functional recovery. Previous studies in the field grafted oligodendrocyte progenitors, nonspinal neural stem cells or primary spinal neural progenitors. Here we sought to improve functional outcomes by grafting clinically compatible spinal cord neural stem cells derived from human embryonic stem cells (H9-scNSCs). H9-scNSCs significantly improved functional outcomes on a skilled hand task 9.2-fold (P = 2.5 × 10

Identifiers

PMID41249838
PMCPMC12802577

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.