ReviewClinical and experimental medicine2025
Disinfectant-induced bacterial resistance and antibiotic cross-resistance-mechanisms and clinical relevance.
Review in Clinical and experimental medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed.
- Desiccation tolerance as a driver of environmental persistence and transmission in nosocomial bacterial pathogens.Infection and immunity · 2026Review
- Effectiveness of Hydrogen Peroxide Nebulization Combined with Manual Cleaning in Reducing Surface-Associated Microorganisms in an Indoor Fitness Environment.Microorganisms · 2026Article
- Exploratory Evaluation of Susceptibility Patterns of Clinical Isolates ofAntibiotics (Basel, Switzerland) · 2026Article
- Biofilm Formation and Plastic Degradation in Bacteria from Different Environments: Evidence for Phenotypic Acclimation and Metabolic Exaptation.Microorganisms · 2026Article
- Cutting-Edge Smart Hydrogel Platforms for Improved Wound Healing.Pharmaceutics · 2026Review
- Driving Antibiotic Resistance Evolution ofMicroorganisms · 2026Article
- Antimicrobial Resistance: A Bibliometric Review of Patient Health, Mechanisms, and Therapeutic Strategies.Pathogens (Basel, Switzerland) · 2026Review
- Environmental Persistence and Genotypic and Phenotypic Characterization ofPathogens (Basel, Switzerland) · 2026Article
- Twenty-Three Years of Surveillance in Chinese Avian Pasteurella multocida Reveals Declining Antimicrobial Resistance but Increasing Therapeutic Challenges.Transboundary and emerging diseases · 2026Article
- Impact of Incremental Antiseptic Selection on Antibiotic Cross-Resistance and Enhanced Biofilm Formation inInternational journal of microbiology · 2026Article
- Surface Contamination by Multidrug-Resistant Gram-Negative Bacteria in a Healthcare Facility: Resistance Determinants and Biofilm-Associated Adhesion.International journal of microbiology · 2026Article
- Clindamycin susceptibility and virulence characterization ofFrontiers in microbiology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The rise of antibiotic-resistant bacteria has become an alarming global health challenge. Disinfectants, such as alcohols, aldehydes, chlorine compounds, phenols, quaternary ammonium compounds (QACs), peroxides, and chlorhexidine, are widely used in healthcare settings as a critical line of defense against infection. Nevertheless, their overuse or misuse, especially at subinhibitory concentrations, can promote the emergence of bacterial resistance, potentially leading to cross-resistance to antibiotics. Several mechanisms, including efflux pump activation, alterations in membrane permeability, and biofilm formation, drive this process. A possible concern, although currently supported by limited and sometimes conflicting evidence-is that biocide-induced resistance might contribute indirectly to adverse clinical outcomes, such as treatment challenges, prolonged hospital stays, and increased healthcare costs. This review examines the molecular mechanisms of disinfectant-induced resistance, the epidemiological impact of multidrug-resistant (MDR) pathogens, and contemporary infection control strategies. Furthermore, the review evaluates the benefits and risks associated with disinfectant use, underscoring the necessity for optimized, evidence-based disinfection protocols to minimize the development of resistance while ensuring effective infection prevention.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.