ArticleEuropean journal of nuclear medicine and molecular imaging2026
Whole-body
Article in European journal of nuclear medicine and molecular imaging, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
5 citing papers in PubMed.
- Whole-bodyEuropean journal of nuclear medicine and molecular imaging · 2026Article
- How organs react under fasting or glucose-insulin status: a self-controlled study usingEuropean journal of nuclear medicine and molecular imaging · 2026Article
- A network analysis of whole-body [European journal of nuclear medicine and molecular imaging · 2026Article
- [18 F]FDG PET unveils a cachexia-specific multiorgan metabolic phenotype and identifies patients with poor prognosis in locally advanced rectal cancer.European journal of nuclear medicine and molecular imaging · 2026Article
- Performance of [European journal of nuclear medicine and molecular imaging · 2026Article
Corrections and comments
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Authors and funding
14 authors.
Funding
Abstract
purposeEarly disruptions in systemic glucose regulation may occur even before overt glycemic abnormalities manifest. This study investigated whether patterns of inter-regional glucose uptake coordination, derived from whole-body ¹⁸F-FDG PET/CT, could reveal latent subclinical metabolic phenotypes among normoglycemic adults.
methodsWe analyzed 536 clinically normoglycemic adults (fasting blood glucose < 6.1 mmol/L) who underwent whole-body ¹⁸F-FDG PET/CT. For each subject, pairwise lean body mass normalized standardized uptake value ratios (SUL
resultsTwo distinct metabolic phenotypes were identified within the normoglycemic cohort (Phenotype A and Phenotype B), with no significant differences in age, sex, BMI, or fasting blood glucose. Phenotype A was characterized by lower myocardium-to-peripheral ratios (versus adipose, skeletal muscle, and lung) and higher brain-to-myocardium and brain-to-fat ratios compared to Phenotype B. At the network level, Phenotype A showed stronger positive correlations between myocardial and peripheral uptakes, indicating tighter systemic coupling despite reduced relative cardiac allocation. These patterns qualitatively mirrored those observed in prediabetic and diabetic groups.
conclusionWhole-body ¹⁸F-FDG PET/CT identified metabolically distinct phenotypes in adults with normal fasting glucose, differentiated by both pairwise uptake ratios and systemic network coordination. These findings highlight latent metabolic heterogeneity in clinically healthy individuals and provide a basis for future investigations into early systemic metabolic alterations.
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Registered trials
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