Evidence map›Paper›PMID 41249678›Full record

Observational studyCJEM2026

Diagnostic yield of imaging for pulmonary embolism by presenting complaint in the emergency department: an observational study.

Federico Germini, Fayad Al-Haimus, Yang Hu, Joshua Klyn, Rick Ikesaka, Natasha Clayton, Quazi Ibrahim, Noel Chan, Kerstin de Wit

Abstract readObservational StudyMulticenter Study
PubMed Publisher
In one paragraph

Observational study in CJEM, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Federico GerminiDepartment of Medicine, McMaster University, and Thrombosis and Atherosclerosis Research Institute (TaARI), Hamilton, ON, Canada. germinif@mcmaster.ca.ORCID 0000-0002-0802-3616
Fayad Al-HaimusDivision of Emergency Medicine, Department of Medicine, University of Toronto, Toronto, ON, Canada.
Yang HuDepartment of Medicine, McMaster University, and Thrombosis and Atherosclerosis Research Institute (TaARI), Hamilton, ON, Canada.
Joshua KlynDepartment of Medicine, McMaster University, Hamilton, ON, Canada.
Rick IkesakaDepartment of Medicine, McMaster University, Hamilton, ON, Canada.
Natasha ClaytonDepartments of Emergency Medicine and Medicine, Queens University, Kingston, ON, Canada.
Quazi IbrahimDepartment of Health Research Methods, Evidence, and Impact (HEI), McMaster University, Hamilton, ON, Canada.
Noel ChanDepartment of Medicine, McMaster University, Hamilton, ON, Canada.
Kerstin de WitDepartments of Emergency Medicine and Medicine, Queens University, Kingston, ON, Canada.

Funding

Canadian Association of Emergency PhysiciansCanadian Venous Thromboembolism Research
6 · The paper itself

Abstract

objectivesOur primary objective was to determine whether the yield of pulmonary embolism imaging in the emergency department (ED) is different for patients presenting with "chest pain with cardiac features" than with other complaints. The yield of imaging was defined as the proportion of imaging tests that were positive for pulmonary embolism. Secondary objectives were to estimate the prevalence of pulmonary embolism, the use of imaging, and the yield of imaging for each presenting complaint category. Our hypothesis was that the presenting complaint influences the physician's threshold for requesting imaging.

methodsWe performed an observational health records review study including all adult patient visits between 2018 and 2019 in three EDs in Hamilton (Ontario), Canada. The primary outcome was the diagnostic yield of imaging (computed tomography pulmonary angiogram or ventilation/perfusion scan). We performed a multivariable regression analysis using a generalized linear model, adjusting for confounders.

resultsDuring the study period, 518,787 patients were assessed and 6,700 received imaging for pulmonary embolism. Among the 29,834 triaged as having chest pain with cardiac features, 1,440 (4.8%) received imaging. Among the 488,953 patients with any other presenting complaint, 5,260 (1.1%) received imaging. The diagnostic yield of imaging was 4.2% for patients with chest pain with cardiac features, 8.6% for those with other presenting complaints, with an adjusted odds ratio of 0.62 (95% confidence interval: 0.45-0.87). The prevalence of pulmonary embolism at 30 days was 0.20% in patients with chest pain with cardiac features and 0.10% for all other presenting complaints.

conclusionsThe lower yield despite a higher prevalence means that the threshold for ordering imaging in people presenting to the ED with chest pain with cardiac features was lower than in other patients. Clinicians should keep in mind this possible bias when assessing their patients.

Indexed as

Chest PainComputed Tomography AngiographyEmergency Service, HospitalPulmonary EmbolismAdultAgedEmergency Room VisitsFemaleHumansMaleMiddle AgedOntarioRetrospective StudiesVentilation-Perfusion ScanComputed tomographyDiagnosisPulmonary embolism

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.