Evidence map›Paper›PMID 41249656›Full record

ArticleNature methods2025

A multi-omics molecular landscape of 30 tissues in aging female rhesus macaques.

Gong-Hua Li, Xiang-Qing Zhu, Fu-Hui Xiao, Xilong Zhao, Longbao Lv, Fan-Qian Yin, Le Chang, Ming-Xia Ge, Qiang Wang, Jing Zhao and 8 more

Abstract read
PubMed Publisher
In one paragraph

Article in Nature methods, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Gong-Hua Li *State Key Laboratory of Genetic Evolution & Animal Models, National Resource Center for Non-Human Primates, Kunming Primate Research Center, Research Facility for Phenotypic & Genetic Analysis of Model Animals (Primate Facility), Key Laboratory of Healthy Aging Research of Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China.ORCID http://orcid.org/0000-0002-9311-6613
Xiang-Qing Zhu *Stem Cells and Immune Cells Biomedical Techniques Integrated Engineering Laboratory of State and Regions, Cell Therapy Technology Transfer Medical Key Laboratory of Yunnan Province, Basic Medical Laboratory, 920th Hospital of the PLA Joint Logistics Support Force, Kunming, China.
Fu-Hui Xiao *State Key Laboratory of Genetic Evolution & Animal Models, National Resource Center for Non-Human Primates, Kunming Primate Research Center, Research Facility for Phenotypic & Genetic Analysis of Model Animals (Primate Facility), Key Laboratory of Healthy Aging Research of Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China.ORCID http://orcid.org/0000-0001-7478-7801
Xilong ZhaoStem Cells and Immune Cells Biomedical Techniques Integrated Engineering Laboratory of State and Regions, Cell Therapy Technology Transfer Medical Key Laboratory of Yunnan Province, Basic Medical Laboratory, 920th Hospital of the PLA Joint Logistics Support Force, Kunming, China.
Longbao LvState Key Laboratory of Genetic Evolution & Animal Models, National Resource Center for Non-Human Primates, Kunming Primate Research Center, Research Facility for Phenotypic & Genetic Analysis of Model Animals (Primate Facility), Key Laboratory of Healthy Aging Research of Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China.
Fan-Qian YinState Key Laboratory of Genetic Evolution & Animal Models, National Resource Center for Non-Human Primates, Kunming Primate Research Center, Research Facility for Phenotypic & Genetic Analysis of Model Animals (Primate Facility), Key Laboratory of Healthy Aging Research of Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China.ORCID http://orcid.org/0000-0002-6620-5733
Le ChangStem Cells and Immune Cells Biomedical Techniques Integrated Engineering Laboratory of State and Regions, Cell Therapy Technology Transfer Medical Key Laboratory of Yunnan Province, Basic Medical Laboratory, 920th Hospital of the PLA Joint Logistics Support Force, Kunming, China.
Ming-Xia GeState Key Laboratory of Genetic Evolution & Animal Models, National Resource Center for Non-Human Primates, Kunming Primate Research Center, Research Facility for Phenotypic & Genetic Analysis of Model Animals (Primate Facility), Key Laboratory of Healthy Aging Research of Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China.
Qiang WangStem Cells and Immune Cells Biomedical Techniques Integrated Engineering Laboratory of State and Regions, Cell Therapy Technology Transfer Medical Key Laboratory of Yunnan Province, Basic Medical Laboratory, 920th Hospital of the PLA Joint Logistics Support Force, Kunming, China.
Jing ZhaoStem Cells and Immune Cells Biomedical Techniques Integrated Engineering Laboratory of State and Regions, Cell Therapy Technology Transfer Medical Key Laboratory of Yunnan Province, Basic Medical Laboratory, 920th Hospital of the PLA Joint Logistics Support Force, Kunming, China.
Chuan TianStem Cells and Immune Cells Biomedical Techniques Integrated Engineering Laboratory of State and Regions, Cell Therapy Technology Transfer Medical Key Laboratory of Yunnan Province, Basic Medical Laboratory, 920th Hospital of the PLA Joint Logistics Support Force, Kunming, China.
Zian LiStem Cells and Immune Cells Biomedical Techniques Integrated Engineering Laboratory of State and Regions, Cell Therapy Technology Transfer Medical Key Laboratory of Yunnan Province, Basic Medical Laboratory, 920th Hospital of the PLA Joint Logistics Support Force, Kunming, China.
Guangping RuanStem Cells and Immune Cells Biomedical Techniques Integrated Engineering Laboratory of State and Regions, Cell Therapy Technology Transfer Medical Key Laboratory of Yunnan Province, Basic Medical Laboratory, 920th Hospital of the PLA Joint Logistics Support Force, Kunming, China.
Rongqing PangStem Cells and Immune Cells Biomedical Techniques Integrated Engineering Laboratory of State and Regions, Cell Therapy Technology Transfer Medical Key Laboratory of Yunnan Province, Basic Medical Laboratory, 920th Hospital of the PLA Joint Logistics Support Force, Kunming, China.
Jing GaoStem Cells and Immune Cells Biomedical Techniques Integrated Engineering Laboratory of State and Regions, Cell Therapy Technology Transfer Medical Key Laboratory of Yunnan Province, Basic Medical Laboratory, 920th Hospital of the PLA Joint Logistics Support Force, Kunming, China.
Lihua MaStem Cells and Immune Cells Biomedical Techniques Integrated Engineering Laboratory of State and Regions, Cell Therapy Technology Transfer Medical Key Laboratory of Yunnan Province, Basic Medical Laboratory, 920th Hospital of the PLA Joint Logistics Support Force, Kunming, China.
Xing-Hua PanStem Cells and Immune Cells Biomedical Techniques Integrated Engineering Laboratory of State and Regions, Cell Therapy Technology Transfer Medical Key Laboratory of Yunnan Province, Basic Medical Laboratory, 920th Hospital of the PLA Joint Logistics Support Force, Kunming, China. xinghuapan@aliyun.com.ORCID http://orcid.org/0000-0002-4277-2100
Qing-Peng KongState Key Laboratory of Genetic Evolution & Animal Models, National Resource Center for Non-Human Primates, Kunming Primate Research Center, Research Facility for Phenotypic & Genetic Analysis of Model Animals (Primate Facility), Key Laboratory of Healthy Aging Research of Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China. kongqp@mail.kiz.ac.cn.ORCID http://orcid.org/0000-0002-6046-4494

Funding

National Natural Science Foundation of China (National Science Foundation of China) 82430049
6 · The paper itself

Abstract

A systematic investigation of aging patterns across virtually all major tissues in nonhuman primates, our evolutionarily closest relatives, can provide valuable insights into tissue aging in humans, which is still elusive largely due to the difficulty in sampling. Here, we generated and analyzed multi-omics data, including transcriptome, proteome and metabolome, from 30 tissues of 17 female rhesus macaques (Macaca mulatta) aged 3-27 years. We found that certain molecular features, such as increased inflammation, are consistent across tissues and align with findings in mice and humans. We further revealed that tissue aging in macaques is asynchronous and can be classified into two distinct types, with one type exhibiting more pronounced aging degree, likely associated with decreased mRNA translation efficiency, and predominantly contributing to whole-body aging. This work provides a comprehensive molecular landscape of aging in nonhuman primate tissues and links translation efficiency to tissue-specific aging.

Indexed as

AgingMacaca mulattaMetabolomeProteomeTranscriptomeAnimalsFemaleGene Expression ProfilingMetabolomicsMultiomicsProteomicsProteome

Identifiers

PMID41249656

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.