Evidence map›Paper›PMID 41249632›Full record

ArticleJournal of medical toxicology : official journal of the American College of Medical Toxicology2026

Survival of Acute-on-Chronic 2,4-Dinitrophenol Overdose with Associated Pharmacokinetics.

Annie Silvester, Zeff Koutsogiannis, Stacey Richards, David Thomson, Anselm Wong

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of medical toxicology : official journal of the American College of Medical Toxicology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Annie SilvesterVictorian Poisons Information Centre, VIC, Melbourne, Australia. Annie.Silvester@austin.org.au.ORCID http://orcid.org/0009-0009-1540-1628
Zeff KoutsogiannisVictorian Poisons Information Centre, VIC, Melbourne, Australia.
Stacey RichardsNSW Health Pathology, NSW, Newcastle, Australia.
David ThomsonDepartment of Critical Care, Austin Hospital, Melbourne, VIC, Australia.
Anselm WongVictorian Poisons Information Centre, VIC, Melbourne, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introduction2,4-dinitrophenol (DNP) is an uncoupler of oxidative phosphorylation and is highly toxic in overdose. CASE REPORT: We present a case of an 18-year-old female who survived an acute-on-chronic DNP overdose resulting in hypermetabolic state and widespread ST depression with associated troponin I elevation. Serial DNP levels are plotted for this patient, demonstrating first order kinetics with a half-life of 18 h. DISCUSSION: Survival in this case may be attributed to early management of hyperthermia and hypermetabolic state, as well as the acute-on-chronic nature of the overdose. Human pharmacokinetic data for DNP in overdose are rare, as are cases with ST-segment changes.

Indexed as

2,4-DinitrophenolDrug OverdoseAdolescentFemaleHumans2,4-Dinitrophenol2,4-dinitrophenolElectrocardiogramHalf-lifeHyperthermiaPharmacokinetic

Identifiers

PMID41249632
PMCPMC12834864

What OpenQuestion holds

Textmetadata
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.