ArticleEMBO reports2025
CTRP9 engages AdipoR1 and promotes T cell glycolysis and immunity.
Kunming Li, Jiansong Zhang, Kang Li, Haokai Chen, Wenhai Deng, Wenzhuo Rao, Ming Geng, Yuying Zheng, Xiumei Wei, Jialong Yang
Abstract read
In one paragraphArticle in EMBO reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
10 authors.
Kunming Li *State Key Laboratory of Estuarine and Coastal Research, School of Life Sciences, East China Normal University, 200241, Shanghai, China.ORCID 0000-0001-5065-6399 Jiansong Zhang *State Key Laboratory of Estuarine and Coastal Research, School of Life Sciences, East China Normal University, 200241, Shanghai, China.
Kang Li *State Key Laboratory of Estuarine and Coastal Research, School of Life Sciences, East China Normal University, 200241, Shanghai, China.
Haokai Chen *State Key Laboratory of Estuarine and Coastal Research, School of Life Sciences, East China Normal University, 200241, Shanghai, China.
Wenhai Deng *School of Laboratory Medicine and Life Science, Wenzhou Medical University, 325035, Wenzhou, China.
Wenzhuo RaoState Key Laboratory of Estuarine and Coastal Research, School of Life Sciences, East China Normal University, 200241, Shanghai, China.
Ming GengState Key Laboratory of Estuarine and Coastal Research, School of Life Sciences, East China Normal University, 200241, Shanghai, China.
Yuying ZhengState Key Laboratory of Estuarine and Coastal Research, School of Life Sciences, East China Normal University, 200241, Shanghai, China.
Xiumei WeiState Key Laboratory of Estuarine and Coastal Research, School of Life Sciences, East China Normal University, 200241, Shanghai, China.ORCID 0000-0002-2253-8181 Jialong YangState Key Laboratory of Estuarine and Coastal Research, School of Life Sciences, East China Normal University, 200241, Shanghai, China. jlyang@bio.ecnu.edu.cn.ORCID 0000-0002-3112-5012 Funding
MOST | National Key Research and Development Program of China (NKPs) 2022YFD2400804MOST | National Natural Science Foundation of China (NSFC) 32373165National Science Foundation of Shanghai 24ZR1419700Shanghai Sailing Program 24YF2710300
6 · The paper itselfAbstract
The adiponectin (ADPN) receptor (AdipoR) modulates T-cell responses, but its effects remain controversial since signaling can either promote or inhibit T-cell function. Interaction with the ligand ADPN inhibits T-cell responses, but given the existence of multiple AdipoR ligands, we hypothesize that ligand diversity underlies its differential effect in T-cell immunity. To test this, we use tilapia and mouse models. Tilapia encodes AdipoR1 but lacks ADPN. Instead, an alternative adipokine, CTRP9, engages AdipoR1. We find CTRP9-AdipoR1 interaction triggers Ca
Indexed as
AdiponectinGlycolysisReceptors, AdiponectinT-LymphocytesAnimalsCell ProliferationGlycoproteinsHumansLymphocyte ActivationMiceSignal TransductionAdiponectinadiponectin receptor 1, mouseCTRP9 protein, mouseGlycoproteinsReceptors, AdiponectinAdiponectinAdipoR1CTRP9GlycolysisT Cell Immunity
Identifiers
PMID41249580
PMCPMC12714829
What OpenQuestion holds
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LicenceCC BY
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