Evidence map›Paper›PMID 41249545›Full record

ReviewFunctional & integrative genomics2025

Small RNAs big impact: a review on microRNA-mediated tolerance in wheat under terminal heat.

Sonal Warkad, Ashok Kumar, Mallesh Gampa, Suneha Goswami, Vinutha T, Sudhir Kumar, Monika Dalal, Dwijesh Mishra, Girish K Jha, Viswanathan C and 1 more

Abstract readReview
PubMed Publisher
In one paragraph

Review in Functional & integrative genomics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Sonal WarkadDivision of Biochemistry, New Delhi, India.
Ashok KumarDivision of Biochemistry, New Delhi, India.
Mallesh GampaDivision of Biochemistry, New Delhi, India.
Suneha GoswamiDivision of Biochemistry, New Delhi, India.
Vinutha TDivision of Biochemistry, New Delhi, India.
Sudhir KumarDivision of Plant Physiology, ICAR-Indian Agricultural Research Institute, New Delhi, 110012, India.
Monika DalalICAR- National Institute of Plant Biotechnology, New Delhi, 110012, India.
Dwijesh MishraICAR- Indian Agricultural Statistics Research Institute, New Delhi, 110012, India.
Girish K JhaICAR- Indian Agricultural Statistics Research Institute, New Delhi, 110012, India.
Viswanathan CDivision of Plant Physiology, ICAR-Indian Agricultural Research Institute, New Delhi, 110012, India.
Ranjeet R KumarDivision of Biochemistry, New Delhi, India. ranjeetranjaniari@gmail.com.

Funding

Indian Council of Agricultural Research CABinIndian Council of Agricultural Research NICRA
6 · The paper itself

Abstract

MicroRNAs (miRNAs) are key regulators of gene expression in plant responses to abiotic stresses, including heat stress. High temperatures during the critical developmental stages of wheat (Triticum aestivum L.) drastically limit growth and production. Recent research has found that specific miRNAs regulate molecular complexes and physiological responses by targeting transcription factors, heat shock proteins, and signaling components, thereby modulating heat stress tolerance pathways. This review highlights current knowledge about heat-responsive miRNAs in wheat, including their validated targets and functional involvement in thermotolerance. In addition, we summarized the potential CRISPR/Cas9 (Clustered Regularly Interspaced Short Palindromic Repeats /CRISPR associated protein 9) genome editing tool for precise alteration of miRNA genes or their targets, degradome profiling, the secondary structure of miRNA, and how interplay of miRNAs with HSFs and HSPs in target gene regulation to improve heat resilience. A comprehensive understanding of miRNA-regulated networks presents novel possibilities for developing climate-resilient wheat varieties, thereby ensuring food security in the face of global warming.

Indexed as

Heat-Shock ResponseMicroRNAsRNA, PlantThermotoleranceTriticumCRISPR-Cas SystemsGene Expression Regulation, PlantMicroRNAsRNA, PlantHeat shock proteins (HSPs)Heat transcription factors (HSFs)MicroRNAs (miRNAs)Target gene regulationTerminal heat stressThermotoleranceWheat

Identifiers

PMID41249545

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.