Evidence map›Paper›PMID 41249488›Full record

ArticleOncogene2025

Circular RNA CLASP1 modulates the GLI1/SNAIL axis and enhances macrophage polarization in breast cancer.

Lijun Zhou, Mei Liu, Fujun Liu, Zhengkun Wang, Xinyu Li, Xiaoyu Peng, Wenqiang Ma, Peilan Guo, Lifang Yuan, Slawomir Wolczynski and 3 more

Abstract read
PubMed Publisher
In one paragraph

Article in Oncogene, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Lijun Zhou *State Key Laboratory of Animal Biotech Breeding, College of Biological Sciences, China Agricultural University, Beijing, China.
Mei Liu *Department of Pathology, The Sixth Medical Center of Chinese PLA General Hospital, Beijing, China.
Fujun LiuShandong Stem Cell Engineering Technology Research Center, Yantai Yuhuangding Hospital Affiliated to Qingdao University, Shandong, China.
Zhengkun WangState Key Laboratory of Animal Biotech Breeding, College of Biological Sciences, China Agricultural University, Beijing, China.
Xinyu LiShandong Provincial Hospital Affiliated to Shandong First Medical University, Shandong, China.
Xiaoyu PengState Key Laboratory of Animal Biotech Breeding, College of Biological Sciences, China Agricultural University, Beijing, China.
Wenqiang MaState Key Laboratory of Animal Biotech Breeding, College of Biological Sciences, China Agricultural University, Beijing, China.
Peilan GuoState Key Laboratory of Animal Biotech Breeding, College of Biological Sciences, China Agricultural University, Beijing, China.
Lifang YuanShandong Stem Cell Engineering Technology Research Center, Yantai Yuhuangding Hospital Affiliated to Qingdao University, Shandong, China.
Slawomir WolczynskiDepartment of Reproduction and Gynecological Endocrinology, Medical University of Bialystok, Bialystok, Poland.
Nafis Ahmed RahmanDepartment of Reproduction and Gynecological Endocrinology, Medical University of Bialystok, Bialystok, Poland.
Wei SongShandong Provincial Hospital Affiliated to Shandong First Medical University, Shandong, China.
Xiangdong LiState Key Laboratory of Animal Biotech Breeding, College of Biological Sciences, China Agricultural University, Beijing, China. xiangdongli68@126.com.ORCID 0000-0003-2261-2393

Funding

National Natural Science Foundation of China (National Science Foundation of China) 82171854
6 · The paper itself

Abstract

Breast cancer (BC) is the most prevalent malignancy among women worldwide. Growing evidence highlights the crucial role of circular RNAs (circRNAs) in BC carcinogenesis; however, their underlying mechanisms remain largely unknown. In this study, we identify circCLASP1, which is significantly upregulated in BC tissues (n = 65) and serum samples (n = 61). Its expression correlates with lymph node metastasis, ki67 expression, and tumor size. Receiver operation characteristic (ROC) curve analysis reveals area under the curve (AUC) values of 0.8196 (BC tissues) and 0.8902 (BC serum), respectively. Functionally, circCLASP1 knockdown significantly suppresses BC cell proliferation, migration, and invasion. Mechanistically, circCLASP1 prevents the ubiquitin-mediated degradation of GLI1 protein by facilitating its interaction with CCT2, thereby stabilizing GLI1. Moreover, circCLASP1 enhances the nuclear accumulation of GLI1, leading to increased SNAIL expression and thereby upregulating the expression of CCL2 and CCL5, which in turn promotes macrophage M2 polarization, ultimately resulting in BC progression and subsequent lung metastasis. Further analysis reveals that U2AF2 regulates circCLASP1 biogenesis. Collectively, these findings demonstrate that circCLASP1 promotes BC progression and an immunosuppressive microenvironment via the CCT2/GLI1/SNAIL axis, highlighting its potential as a prognostic biomarker and therapeutic target for BC.

Indexed as

Breast NeoplasmsMacrophagesRNA, CircularSnail Family Transcription FactorsZinc Finger Protein GLI1AnimalsBiomarkers, TumorCell Line, TumorCell MovementCell ProliferationFemaleGene Expression Regulation, NeoplasticHumansMiceMiddle AgedBiomarkers, TumorGLI1 protein, humanRNA, CircularSNAI1 protein, humanSnail Family Transcription FactorsZinc Finger Protein GLI1

Identifiers

PMID41249488

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.