Evidence map›Paper›PMID 41249486›Full record

ArticleJournal of exposure science & environmental epidemiology2026

Characterizing variability in personal chemical exposure to improve exposomics.

Lisa M Bramer, Holly M Dixon, Alison E Clark, Diana Rohlman, Katrina M Waters, Kim A Anderson

Abstract read
In one paragraph

Article in Journal of exposure science & environmental epidemiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Lisa M BramerPacific Northwest National Laboratory, Biological Sciences Division, Richland, WA, USA.ORCID http://orcid.org/0000-0002-8384-1926
Holly M DixonEnvironmental and Molecular Toxicology, Food Safety and Environmental Stewardship Program, Oregon State University, Corvallis, OR, USA.ORCID http://orcid.org/0000-0003-0326-4477
Alison E ClarkEnvironmental and Molecular Toxicology, Food Safety and Environmental Stewardship Program, Oregon State University, Corvallis, OR, USA.ORCID http://orcid.org/0009-0005-3857-5576
Diana RohlmanEnvironmental and Molecular Toxicology, Food Safety and Environmental Stewardship Program, Oregon State University, Corvallis, OR, USA.ORCID http://orcid.org/0000-0002-3982-0327
Katrina M WatersPacific Northwest National Laboratory, Biological Sciences Division, Richland, WA, USA.ORCID http://orcid.org/0000-0003-4696-5396
Kim A AndersonEnvironmental and Molecular Toxicology, Food Safety and Environmental Stewardship Program, Oregon State University, Corvallis, OR, USA. kim.anderson@oregonstate.edu.ORCID http://orcid.org/0000-0002-5258-2925

Funding

Research Experience and Training Coordination CoreP42ES016465 · NIEHS · OREGON STATE UNIVERSITY · PI Robyn L Tanguay · 2009 to 2026
$52.5M
MODE OF ACTION OF ENVIRONMENTAL TOXICANTST32ES007060 · NIEHS · OREGON STATE UNIVERSITY · PI Jamie DeWitt, Siva Kumar Kolluri · 1985 to 2026
$11.6M
Zebrafish Biomedical Research Facility CoreP30ES030287 · NIEHS · OREGON STATE UNIVERSITY · PI Jamie DeWitt · 2020 to 2026
$9.8M
Personal Envl Exposure Assmt using Wristbands for Epi Studies in Disadv CommR33ES024718 · NIEHS · OREGON STATE UNIVERSITY · PI ANDERSON, KIM A., HERBSTMAN, JULIE BETH · 2016 to 2019
$2.3M
Personal Environmental Exposure Assessment using Wristbands for Epidemiological Studies in Disadvantaged CommunitiesR21ES024718 · NIEHS · OREGON STATE UNIVERSITY · PI ANDERSON, KIM A., HERBSTMAN, JULIE BETH · 2015 to 2015
$265k
NIEHS NIH HHS P30 ES030287NIEHS NIH HHS P42 ES016465NIEHS NIH HHS R21 ES024718NIEHS NIH HHS R33 ES024718NIEHS NIH HHS T32 ES007060
6 · The paper itself

Abstract

backgroundUnderstanding how chemical exposure varies within and between people over time is a critical component of characterizing the exposome-the totality of lifetime exposures. However, variability remains an understudied aspect of exposomic research.

objectiveOur objective was to investigate trends in variability for chemical exposure data between and within people that appear across differing study designs.

methodsThirty-five people in Eugene, Oregon, and 46 people in St. Helens, Oregon, wore silicone wristbands over multiple seasons, including a span of heavy wildfire smoke in Eugene. Each participant wore between four and 14 wristbands. We analyzed 586 wristbands for 94 (Eugene) and 58 (St. Helens) chemicals. While analytic tests differed between the studies, the same 43 polycyclic aromatic hydrocarbons (PAHs) were measured in both studies. We also evaluated three environmental variables for their impact on chemical concentrations. We fit generalized mixed effects models to each chemical, and used variance partitioning to understand and quantify sources of variability across environmental factors and inter- and intra-individual variables.

resultsWe observed PAHs that were consistent within people across different days. For a subset of these PAHs, results did not agree well between studies, indicating the importance of measuring chemical data at different time points across studies. Environmental variables were not sufficient for explaining data variability for most chemicals. Only 21% and 30% of the modeled chemicals for Eugene and St. Helens, respectively, had a combined environmental variable R IMPACT STATEMENT: Our manuscript is the largest investigation of intra- and inter- variability in silicone wristband concentrations, containing over 23,000 chemical data points across two different personal chemical exposure studies. Certain chemicals were consistent within people across different days. For a subset of chemicals, results did not agree well between the two wristband studies. Our findings highlight the importance of measuring chemical data at different time points across studies to better understand the exposome. Environmental variables included in this study were not sufficient for explaining the data variability for most chemicals.

Indexed as

Air PollutantsEnvironmental ExposureEnvironmental MonitoringExposomePolycyclic Aromatic HydrocarbonsAdultFemaleHumansMaleMiddle AgedOregonSmokeAir PollutantsPolycyclic Aromatic HydrocarbonsSmoke

Identifiers

PMID41249486
PMCPMC12826124

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.