Evidence map›Paper›PMID 41249485›Full record

ArticleNature immunology2025

Fibroblastic FLT3L supports lymph node dendritic cells in the interfollicular niche.

Sunny Z Wu, Ryan S Lane, Christopher Davidson, Ashley Byrne, Giulia Protti, Ines Marin, Endi K Santosa, Alberto Guanieri, Brandon D Kayser, Hejin Huang and 18 more

Abstract read
PubMed Publisher
In one paragraph

Article in Nature immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

28 authors.

Sunny Z Wu *Ophthalmology and Immunology, Genentech, South San Francisco, CA, USA.ORCID http://orcid.org/0000-0002-6153-0449
Ryan S Lane *Ophthalmology and Immunology, Genentech, South San Francisco, CA, USA.
Christopher DavidsonOphthalmology and Immunology, Genentech, South San Francisco, CA, USA.
Ashley ByrneProteomic and Genomic Technologies, Genentech, South San Francisco, CA, USA.
Giulia ProttiComputational Biology & Translation, Genentech, South San Francisco, CA, USA.
Ines MarinOphthalmology and Immunology, Genentech, South San Francisco, CA, USA.ORCID http://orcid.org/0000-0003-0922-0555
Endi K SantosaOphthalmology and Immunology, Genentech, South San Francisco, CA, USA.
Alberto GuanieriOphthalmology and Immunology, Genentech, South San Francisco, CA, USA.
Brandon D KayserComputational Biology & Translation, Genentech, South San Francisco, CA, USA.
Hejin HuangBiological Research, AI Development, Genentech, South San Francisco, CA, USA.ORCID http://orcid.org/0000-0002-9250-8797
Katherine WilliamsComputational Biology & Translation, Genentech, South San Francisco, CA, USA.ORCID http://orcid.org/0000-0001-8061-0105
Matthew FernandezPathology Labs, Genentech, South San Francisco, CA, USA.
Jian JiangPathology Labs, Genentech, South San Francisco, CA, USA.
Juan ZhangTranslational Immunology, Genentech, South San Francisco, CA, USA.
Raymond AsuncionRSF, Genentech, Dixon, CA, USA.
Apple Cortez VollmersOphthalmology and Immunology, Genentech, South San Francisco, CA, USA.ORCID http://orcid.org/0000-0003-2787-0797
Jérémie DecalfCancer Immunology, Genentech, South San Francisco, CA, USA.
Merone Roose-GirmaMolecular Biology, Genentech, South San Francisco, CA, USA.ORCID http://orcid.org/0000-0003-1601-571X
Wyne P LeeTranslational Immunology, Genentech, South San Francisco, CA, USA.
Lisa McGinnisResearch Pathology, Genentech, South San Francisco, CA, USA.
Varun N KapoorCoherus Oncology, Redwood City, CA, USA.
Soren WarmingMolecular Biology, Genentech, South San Francisco, CA, USA.ORCID http://orcid.org/0000-0002-5721-0741
William StephensonProteomic and Genomic Technologies, Genentech, South San Francisco, CA, USA.ORCID http://orcid.org/0000-0002-3779-417X
Sandra RostPathology Labs, Genentech, South San Francisco, CA, USA.
Christine MoussionOphthalmology and Immunology, Genentech, South San Francisco, CA, USA.
Tommaso BiancalaniBiological Research, AI Development, Genentech, South San Francisco, CA, USA.ORCID http://orcid.org/0000-0001-9104-9755
Sören MüllerComputational Biology & Translation, Genentech, South San Francisco, CA, USA. muels102@gene.com.ORCID http://orcid.org/0000-0001-9490-5270
Shannon J TurleyOphthalmology and Immunology, Genentech, South San Francisco, CA, USA. shannon.turley@gmail.com.ORCID http://orcid.org/0000-0002-0444-3031

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Dendritic cell (DC) homeostasis is maintained in secondary lymphoid organs (SLOs) by Fms-like tyrosine kinase 3 ligand (FLT3L). The specific niche providing this DC growth factor within human and mouse SLOs is unclear. Here we show that Gremlin1 (GREM1)-expressing lymph node fibroblastic reticular cells (FRCs) support DC homeostasis via provision of FLT3L. Grem1-expressing FRCs colocalize with DCs and express FLT3LG/Flt3l in human and mouse lymph nodes. Using a new genetic model, we provide evidence that FLT3L produced by GREM1

Indexed as

Dendritic CellsFibroblastsLymph NodesMembrane ProteinsAnimalsHomeostasisHumansIntercellular Signaling Peptides and ProteinsLymphocyte ActivationMiceMice, Inbred C57BLMice, KnockoutMice, Transgenicflt3 ligand proteinIntercellular Signaling Peptides and ProteinsMembrane Proteins

Identifiers

PMID41249485

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.