ArticleCommunications chemistry2025
Palladium-catalyzed selective assembly of carbamoylated indoles and aminophenanthridinones via β-carbon elimination switch.
Article in Communications chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Merging photocatalysis with C-H insertions enabled switchable synthesis of indoles and indolines.Nature communications · 2026Article
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11 authors.
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Abstract
Palladium-catalyzed switchable β-carbon elimination to extrude norbornene for selective synthesis of different heterocyclic skeletons is a long-standing challenge. Herein, we describe the switchable chemoselective synthesis of biologically active C4-carbamoylated indoles and C10-aminophenanthridinones by controlling β-carbon elimination, using chlorocarbamates as C-H carbamoylation reagents. Among them, C4-carbamoylated indoles are used for the synthesis of M2 receptor antagonists and p38α inhibitors. Mechanistic studies show that when β-carbon elimination is inhibited, the catalytic cycle goes through C-N bond coupling and retro-Diels-Alder reaction to generate C4-carbamoylated indoles. Alternatively, when β-carbon elimination to extrude norbornene occurs, an intramolecular C-H arylation cyclization reaction generates C10-aminophenanthridinones.
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