ArticleNPJ digital medicine2025
Timelapse-based 3D reconstruction of blastocysts reveals 3D morphologies of human blastocysts.
Article in NPJ digital medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Contemporary Approaches Towards the Optimization of Embryo Implantation.Journal of clinical medicine · 2026Review
Corrections and comments
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Authors and funding
12 authors.
Funding
Abstract
Assessing blastocysts from a three-dimensional (3D) perspective introduces a novel approach to clinical embryo evaluation. Currently, assisted reproduction laboratories lack clinically compatible methods to reconstruct 3D blastocyst structures without interfering with embryo culture. To address this, we developed an interference-free and non-invasive method that uses widely adopted time-lapse (TL) imaging systems to reconstruct 3D blastocyst structures directly from multi-focal images and quantitatively calculate various 3D morphological parameters, without requiring embryologist intervention. In this study, we reconstructed 3D structures for 2025 blastocysts using 22,275 TL images and analyzed the association between 20 3D morphological features and embryo transfer outcomes. Several parameters were significantly associated with clinical pregnancy and live birth (P < 0.05). This method is fully compatible with current clinical workflows, providing objective and comprehensive 3D data for blastocyst assessment. It holds strong potential for future implementation in standardized and automated embryo selection based on quantitative morphological criteria.
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Registered trials
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