ArticleScientific reports2025
Anti-inflammatory, cytotoxic, and potential wound healing effects of phytofabricated Ehretia rigida leaf aqueous extract-synthesized silver nanoparticles.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Anti-inflammatory activity of Silver Nanoparticles (AgNPs): An Updated Systematic review from in vivo, and in vitro studies.Inflammopharmacology · 2026Pooled it
- Plant-Mediated Silver Nanoparticle Formulations for Wound Healing: A Process-Property-Performance Perspective.Pharmaceutics · 2026Review
- Biogenic Silver Nanoparticles from the Cell-Free Supernatant of Mychonastes sp. B1: Antibacterial and Antibiofilm Effects, and Wound Healing Activity Supported by Gene and Protein Expression Analysis.Molecular biotechnology · 2026Article
- Phytochemical Profiling and Computational Screening ofPharmaceuticals (Basel, Switzerland) · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Chronic wounds are a global burden, which is escalated by diabetes, infections, and antimicrobial resistance. As a result, the combination of traditional herbal remedies with green nanotechnology has gained attention for developing novel and sustainable therapeutic solutions. Despite the promising biological activities of Ehretia rigida (Er), its potential in nanotechnology-driven wound healing remains unexplored. This study investigated the in vitro anti-inflammatory, cytotoxic, and potential wound-healing effects of Er silver nanoparticles (Er-AgNPs). The stability of the Er-AgNPs was tested in various biological media. Anti-inflammatory activity was assessed via inhibition of thermally-induced Bovine serum albumin (BSA) denaturation. Cytotoxicity and wound healing efficacy were evaluated in skin fibroblasts (KMST-6) and keratinocytes (HaCaT) using the Water-Soluble Tetrazolium salt-1 (WST-1) and in vitro scratch assays, respectively. The half maximal inhibitory concentration (IC50) for protein denaturation was 270.8 µg/ml for Er leaf extract and 532.9 µg/ml for Er-AgNPs, indicating stronger anti-inflammatory properties for the Er leaf extract. Er leaf extract and Er-AgNPs showed negligible cytotoxicity to KMST-6 and HaCat at concentrations < 25 µg/ml. Er-AgNPs promoted wound healing by increasing cell migration and wound closure rates in KMST-6 and HaCaT cells compared to the Er leaf extract alone. In conclusion, this study highlighted the potential of integrating traditional herbal medicine with green nanotechnology to develop innovative and effective solutions for treatment and management, fostering advances in sustainable healthcare.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.