Evidence map›Paper›PMID 41249390›Full record

ArticleScientific reports2025

An integrated computational, in vitro and metabolomics approach to the discovery of novel aromatase inhibitors with anti-breast cancer activities.

Arnatchai Maiuthed, Jaruwan Chatwichien, Nichawadee Sandech, Meng Chieh Yang, Sucheewin Krobthong, Pattarawit Rukthong, Jisnuson Svasti, Somsak Ruchirawat, Chatchakorn Eurtivong

Abstract read
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Arnatchai MaiuthedDepartment of Pharmacology, Faculty of Pharmacy, Mahidol University, Bangkok, 10400, Thailand.
Jaruwan ChatwichienProgram in Chemical Sciences, Chulabhorn Graduate Institute, Bangkok, 10210, Thailand.
Nichawadee SandechCentre of Biopharmaceutical Science for Healthy Ageing, Faculty of Pharmacy, Mahidol University, Bangkok, 10400, Thailand.
Meng Chieh YangCentre of Biopharmaceutical Science for Healthy Ageing, Faculty of Pharmacy, Mahidol University, Bangkok, 10400, Thailand.
Sucheewin KrobthongCentre of Biopharmaceutical Science for Healthy Ageing, Faculty of Pharmacy, Mahidol University, Bangkok, 10400, Thailand.
Pattarawit RukthongDepartment of Pharmaceutical Technology, Faculty of Pharmacy, Srinakharinwirot University, Nakhon Nayok, 26120, Thailand.
Jisnuson SvastiLaboratory of Biochemistry, Chulabhorn Research Institute, Bangkok, 10210, Thailand.
Somsak RuchirawatProgram in Chemical Sciences, Chulabhorn Graduate Institute, Bangkok, 10210, Thailand.
Chatchakorn EurtivongDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Mahidol University, Bangkok, 10400, Thailand. chatchakorn.eur@mahidol.edu.

Funding

Thailand Science Research and Innovation RGNS 65-206
6 · The paper itself

Abstract

A novel series of azole and pyrrole-containing pyridinylmethanamine/amide derivatives were identified by virtual screening for inhibition of aromatase. Ten molecules were found to inhibit aromatase with IC

Indexed as

Antineoplastic AgentsAromatase InhibitorsBreast NeoplasmsMetabolomicsAndrostadienesAromataseCell Line, TumorDrug DiscoveryFemaleHumansMCF-7 CellsMolecular Docking SimulationMolecular Dynamics SimulationAndrostadienesAntineoplastic AgentsAromataseAromatase InhibitorsexemestaneBreast cancerEstrogenMetabolomeMolecular dockingVirtual screening

Identifiers

PMID41249390
PMCPMC12623930

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.