ArticleScientific reports2025
Synergistic effects of body fat percentage and C-reactive protein triglyceride-glucose index on cardiovascular disease risk: a Chinese cohort study.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- The Triglyceride-Glucose Index and Its Combination with C-Reactive Protein and Anthropometric Indicators as Biomarkers for Hypertension Among Saudi Adults: A Cross-Sectional Survey.Journal of clinical medicine · 2026Article
- Associations between the C-reactive protein-triglyceride-glucose index and its derived indices and the incidence and progression of cardiometabolic multimorbidity in participants with metabolic dysfunction-associated steatotic liver disease: a large-scale prospective cohort study.Cardiovascular diabetology · 2026Article
- C-reactive protein-triglyceride-glucose index (CTI) as a predictor of chronic liver disease in adults with macrocytic anemia.Scientific reports · 2026Article
- Clinical characteristics and risk factors of antipsychotic-associated metabolic syndrome in bipolar disorder: a retrospective analysis.BMC psychiatry · 2026Article
- C-Reactive Protein-Triglyceride Glucose Index and Mortality in Patients with Ventricular Septal Rupture After Acute Myocardial Infarction.Journal of inflammation research · 2026Article
- Article
- Joint Association of Inflammatory-Metabolic Indices With Risk of Incident Stroke Among Middle-Aged and Older Chinese Adults.Journal of obesity · 2026Article
- CTI-related composite adiposity indices and future cardiovascular disease risk among middle-aged and older Chinese adults.Frontiers in nutrition · 2026Article
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Authors and funding
5 authors.
Funding
Abstract
Obesity, insulin resistance (IR), and inflammation are key modifiable cardiovascular disease (CVD) risk factors. We investigated the synergistic effects of body fat percentage (BFP) and the C-reactive protein-triglyceride-glucose index (CTI) on CVD risk. This prospective cohort included 6303 CVD-free Chinese adults (≥ 45 years) from the CHARLS. BFP was calculated via the CUN-BAE equation; the CTI integrates CRP, triglycerides, and fasting glucose. Multivariate Cox regression was used to assess associations with incident CVD over 7 years. Mediation and receiver operating characteristic (ROC) analyses were used to evaluate pathways and predictive performance. Among 1124 incident CVD cases, concurrent high BFP (> 30.8%) and CTI (> 4.68) showed 1.48-fold higher CVD risk (95% CI 1.21-1.80) versus low-level groups. The combined BFP-CTI model improved prediction (AUC = 0.581; DeLong's P < 0.05) over individual indices. Mediation revealed bidirectional effects: CTI mediated 8.76% of BFP's CVD association, while BFP mediated 12.22% of CTI's effect (P < 0.001). Synergy was strongest in adults ≤ 60y (HR = 1.76, CI 1.25-2.48) and diabetics (HR = 3.52, CI 1.69-7.31). The combination of high BFP and high CTI was associated with a synergistic increase in CVD risk, with bidirectional mediation between adiposity and metabolic-inflammation pathways. Joint assessment enhances risk stratification, particularly in younger and diabetic populations.
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