Evidence map›Paper›PMID 41249365›Full record

ArticleScientific reports2025

Synthesis of a novel specific nectin-4 tumor-targeted peptide optical molecular probe and its preliminary study in lung cancer.

Ting Jiang, Ke Dong, Jianfei Fu, Yong Zheng, Bilian Zhu, Qianqian Zhang, Binjing Jiang, Zhijian Zheng, Mengjie Dong

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In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Ting JiangDepartment of Nuclear Medicine, Affiliated Jinhua Hospital, Zhejiang University School of Medicine, Jinhua, 321000, Zhejiang, China.
Ke DongDepartment of Nuclear Medicine, Affiliated Jinhua Hospital, Zhejiang University School of Medicine, Jinhua, 321000, Zhejiang, China.
Jianfei FuDepartment of Medicine Oncology, Affiliated Jinhua Hospital, Zhejiang University School of Medicine, Jinhua, 321000, Zhejiang, China.
Yong ZhengDepartment of Nuclear Medicine, Affiliated Jinhua Hospital, Zhejiang University School of Medicine, Jinhua, 321000, Zhejiang, China.
Bilian ZhuDepartment of Nuclear Medicine, Affiliated Jinhua Hospital, Zhejiang University School of Medicine, Jinhua, 321000, Zhejiang, China.
Qianqian ZhangDepartment of Nuclear Medicine, Affiliated Jinhua Hospital, Zhejiang University School of Medicine, Jinhua, 321000, Zhejiang, China.
Binjing JiangDepartment of Pathology, Affiliated Jinhua Hospital, Zhejiang University School of Medicine, Jinhua, 321000, Zhejiang, China.
Zhijian ZhengDepartment of Central Laboratory, Affiliated Jinhua Hospital, Zhejiang University School of Medicine, Jinhua, 321000, Zhejiang, China.
Mengjie DongDepartment of Nuclear Medicine, Peking University Shenzhen Hospital, Shenzhen, 518110, China. dongmengjie@126.com.

Funding

Basic Research Foundation JY2023-6-11Jinhua Science and Technology Project Social Development Key project 2022-3-077Jinhua Science and Technology Project Social Development Key project 2023-3-108Jinhua Science and Technology Project Social Development public welfare Project 2024-4-079Youth Research Start-up Fund JY2022-1-03
6 · The paper itself

Abstract

Nectin-4/PVRL-4 is overexpressed in tumors, driving proliferation and invasion. It's a key target for solid tumor therapy. Current tumor imaging methods are inadequate. Studying nectin-4 in lung cancer helps identify diagnostic biomarkers and develop radionuclide probes, intraoperative visualization,and new chemotherapies. High nectin-4 expression in lung cancer tissues was confirmed using TCGA data and IHC. Three optical probes targeting nectin-4 were synthesized. Optimal binding conditions were explored, and binding rates were assessed. Animal experiments showed the probes' specificity and biodistribution. The probes effectively targeted nectin-4, with Cy5.5-nectin-4 PEP 02 showing the highest binding rate. In vivo, the probe targeted lung cancer tissues, indicating potential for intraoperative navigation. Nectin-4 is a promising target for lung cancer and intraoperative navigation, guiding further research.

Indexed as

Cell Adhesion MoleculesLung NeoplasmsMolecular ProbesPeptidesAnimalsCarbocyaninesCell Line, TumorHumansMiceNectinsTissue DistributionCarbocyaninesCell Adhesion MoleculesMolecular ProbesNECTIN4 protein, humanNectinsPeptidesCy5.5Intraoperative navigationLung cancerNear-infrared fluorescence imagingNectin-4Small molecular peptide

Identifiers

PMID41249365
PMCPMC12623819

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.