Observational studyScientific reports2025
Age and sex differences in speech FFR suggest early central auditory aging.
Observational study in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Effect of Lateralization, Age, and Sex on Frequency Following Response in Children: Neural Speech Encoding to a 170 ms [da] Stimulus.Life (Basel, Switzerland) · 2026Article
- The Influence of Sex, Ear, and Age on Auditory Brainstem Responses Recorded with the NeuroAudio System.Diagnostics (Basel, Switzerland) · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study aimed to examine the effects of age and sex on speech-evoked frequency-following response (FFR) latency, amplitude, and spectral features in Turkish-speaking young and middle-aged adults with normal hearing. Moreover, this study aimed to characterize the properties of speech-FFR in native Turkish speakers. A cross-sectional observational design was utilized. Sixty-one right-handed native Turkish speakers with clinically normal hearing were included: Thirty-one were young adults (aged 19-25 years) and 30 were middle-aged adults (aged 40-60 years), with an equal number of males and females in each group. The 40-ms /da/ syllable was presented monaurally to the right ear at 80 dB SPL using alternating polarity. Six wave peaks (V, A, D, E, F, O) were analyzed in both the temporal (latency, amplitude) and spectral (F0, F1, F2) domains. Statistical analyses included independent t-tests, Mann-Whitney U tests, and Spearman's correlation. In the young group, females showed significantly shorter latencies than males across all peaks. In the middle-aged group, this sex difference was limited to A and D peaks. Latencies of D, F, and O waves positively correlated with age, while V wave amplitude negatively correlated with age. No significant sex-related differences were found in amplitude or spectral features. Both age and sex may affect subcortical auditory processing as reflected in Speech-FFR. Latency prolongation and amplitude reduction with advancing age may indicate early neural changes in time domain at the brainstem level, even in adults with normal hearing.These findings suggest potential clinical relevance for Speech FFR and emphasize the need for language specific normative data.
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