ArticleScientific reports2025
Integrated metagenomic and metabolomic analysis reveals microbial metabolite interactions involved in the quality formation of Codonopsis Radix.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Due to the impact of various environmental factors, in conjunction with the ecological adaptability and biochemical diversity of Chinese medicinal materials, Codonopsis Radix from Shanxi Province has developed into two distinct commercial specifications, namely Tai Codonopsis Radix (TCP) and Lu Codonopsis Radix (LCP). The present study examined the relationships between TCP and LCP from Shanxi Province regarding their environment, secondary metabolites, and Traditional Chinese Medicinal plant authenticity using metagenomic, metabolomic, and comprehensive quality assessment methods. The findings revealed that the two types of CPs met the quality standards. With respect to the growing environment, TCP and LCP grow in the same longitudinal extent, with a maximum longitudinal span of only 53'. Both regions presented similar natural environments conducive to the growth of CP. Additionally, the Lobetyolin content in TCP was greater than that in LCP. The soil microbial abundance in the TCP group was considerably significantly greater than that in the LCP group, and a new genus, Ascobolus, was found in TCP. Additionally, comparison of the metallic element data of the two groups soils revealed that the contents of Ti, Mg, Cr (P < 0.01) in the TCP group were significantly greater than those in the LCP group. Through correlation analysis, the ternary network of microbial-metal-metabolite interactions was constructed. The rhizosphere fungus Ascobolus was found to enhance the bioavailability of Zn via mineralization processes, thereby underscoring the significance of rhizosphere microecology in promoting plant growth. This study offers novel insights and approaches for the cultivation and processing of Codonopsis Radix.
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