ArticleScientific reports2025
Understanding the interplay of autistic traits, depression and suicidal ideation in adolescents with major depressive disorder.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Adolescents with autistic traits (ATs) experience higher rates of depression and suicidal behavior. This study aims to investigate the relationship between ATs, depressive symptoms, and suicidal ideation (SI) in adolescents with major depressive disorder (MDD). Seventy adolescents, aged 11-18 and diagnosed with MDD, were included. Participants were evaluated with the ColumbiaSuicide Severity Rating Scale (CSSR-S), Beck Depression Inventory (BDI), and ATs using the Autism Spectrum Quotient (AQ). Three groups were compared: those without suicidal thoughts (ST-), suicidal thoughts (ST+), and suicide attempts (SA). While the SA group scored significantly higher on the C-SSRS, BDI, and AQ compared to the ST- group; ST + and SA groups didn't differ. The mediating role of depression was investigated via a Bayesian mediator analysis for CSSR-S subheaders of current and lifetime suicidal ideation and ideation intensity. The effect of BDI scores on current suicidal ideation was β = 0.08 (CI[0.04-0.13]), which was consistent with lifetime suicidal ideation with the same effect size β = 0.08 (CI[0.03-0.13]). For current suicidal ideation and its intensity, autistic traits had an indirect effect through BDI scores, with an indirect mean of 0.050 (CI[0.02-0.10]). For lifetime suicidal ideation, autistic traits exhibited both a direct (β = 0.09, (CI[0.01-0.16]) and an indirect effect through depression scores, with a mean of 0.052 (CI [0.015-0.102]). The complex interplay between ATs, depressive symptoms, and SI in adolescents diagnosed with MDD suggests that interventions targeting autistic traits may be a useful component of comprehensive mental health strategies for adolescents with MDD and elevated suicidal risk.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.