ArticleScientific reports2025
MiRNAs profile of extracellular vesicles from differentiated endothelial cells treated with chemical environmental pollutant BPA.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
1 citing paper in PubMed.
- Altered miRNA Expression Due to Bisphenol A Exposure and Associated Health Implications: A Narrative Review.Journal of xenobiotics · 2026Review
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Authors and funding
12 authors.
Funding
Abstract
Daily, polluting substances are scattered in the atmosphere by industries, which can potentially damage human health. Particular concern derives from those substances defined as endocrine disruptors Chemicals, which mimic the actions of natural hormones and cause adverse effects on the normal functioning of developmental, metabolic, and reproductive processes like embryonic development, gonad formation, sexual differentiation, and growth, that may lead to the loss of homeostasis. Moreover, perinatal exposure to substances with estrogenic activity may be able to cross the placenta and produce long-lasting consequences in the fetus. Among the potentially contaminating substances involved in endocrine disruption, it is necessary to highlight Bisphenol A (BPA) due to its adverse effects on human health. We used an in vitro model of human periodontal ligament stem cells (hPDLSCs) differentiated into endothelial cells (e-hPDLSCs) to evaluate the angiogenesis effects of BPA. Our data showed that BPA (10 μM) presented a high expression of angiogenesis markers, such as PECAM-1, VEGF, VEGFR, and vWF in hPDLSCs in e-hPDLSCs. The epigenetic mechanism explains these adverse effects caused by BPA, as the vesicles obtained from BPA-treated e-hPDLSCs presented a lower expression of the miRNAs correlated with the angiogenic genes analyzed than the vesicles obtained from untreated e-hPDLSCs.
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