The correlation between myopia severity and stress-strain index (SSI) using the Corneal Visualization Scheimpflug Technology (Corvis ST).

Xiaorui Wang, Dan Wang, Sally Hayes, Siân R Morgan, Craig Boote, Yuhui Duan, Shengjian Mi, Colm McAlinden

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Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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Xiaorui WangDepartment of Ophthalmology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.

Dan WangDepartment of Ophthalmology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.

Sally HayesStructural Biophysics Group, School of Optometry and Vision Sciences, Cardiff University, Cardiff, Wales, UK.

Siân R MorganStructural Biophysics Group, School of Optometry and Vision Sciences, Cardiff University, Cardiff, Wales, UK.

Craig BooteStructural Biophysics Group, School of Optometry and Vision Sciences, Cardiff University, Cardiff, Wales, UK.

Yuhui DuanXi'an Gaoxin Hospital, Xi'an, Shaanxi, China. duan.yuhui@000516.cn.

Shengjian MiDepartment of Ophthalmology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China. shengjian.mi@163.com.

Colm McAlindenEye & ENT Hospital of Fudan University, Shanghai, China.

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6 · The paper itself

Abstract

This study aimed to investigate the correlation between myopia severity and the stress-strain index (SSI), measured with the Corneal Visualization Scheimpflug Technology (Corvis ST) device. The subjects were divided into two groups, based on both the axial length (AL) and spherical equivalent refraction (SER): 22-26.00 AL group (22 mm < AL < 26.00 mm) associated with SER of less than - 6.00D, and ≥ 26.00 AL group (AL ≥ 26.00 mm) associated with SER over - 6.00D. The differences in the Corvis ST-derived dynamic corneal response parameters and stiffness parameters between the two groups were investigated. The correlation between SSI and AL, SER, age, ratio of AL to radius of corneal curvature (CR) (AL/CR), and axial length minus anterior chamber depth (ACD) (AL-ACD) were analyzed. The SSI (0.95 ± 0.13 in the 22-26.00 AL group and 0.86 ± 0.15 in the ≥ 26.00 AL group) were significantly different between the two groups (P < 0.01). In the ≥ 26.00 AL group, there was evidence of a weak negative correlation between SSI and AL (r = - 0.265, P < 0.01), AL/CR (r = - 0.376, P < 0.01), and AL-ACD (r = - 0.224, P < 0.01); and a weak positive correlation between SSI and SER (r = 0.251, P < 0.01). However, in the 22-26.00 AL group, there was no correlation between SSI and AL, AL-ACD, AL/CR or SER (P > 0.05). SSI was significantly correlated with AL, which is the major determinant of SER, in the ≥ 26.00 AL group. This correlation was not affected with CR and ACD, as both AL/CR and AL-ACD also correlated with SSI at the same degree.

Indexed as

CorneaMyopiaAdultFemaleHumansMaleRefraction, OcularSeverity of Illness IndexYoung AdultCorneal biomechanicsCorvis STHigh myopiaMyopia severityStiffnessStress–strain index

Identifiers

PMID41249238

DOI10.1038/s41598-025-23834-x

PMCPMC12623436

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